生物活性压电陶瓷在植骨材料的研究进展

Research Progress of Electro-Bioactive Piezoelectric Ceramic in Bone Graft Materials

目前临床上的植骨材料在使用中有着一定的局限性,例如生物活性不足、骨折不愈合、成骨量有限、材料降解速度与组织生长不匹配等问题。研究具备成骨性能的新型生物活性骨修复材料是目前骨组织工程领域研究的热点和重点之一。介绍了CaTiO_(3)、BaTiO_(3)基无铅压电陶瓷、[(K,Na)NbO_(3)]基(KNN基)无铅压电陶瓷及LiNbO3作为植骨材料的研究进展。生物压电陶瓷有着较好的细胞相容性和组织相容性,具有成为骨替代物的潜力。

At present,clinical bone graft materials have some limitations in their use,such as insufficient biological activity,nonunion of fracture,limited bone formation,mismatch of material degradation rate and tissue growth,etc。Therefore,the research of new bioactive bone repair materials with osteogenic properties is one of the hotspots and emphases in the field of bone tissue engineering。In this paper,the piezoelectric properties and repair mechanism of bone and the development of biomaterials for bone repair are reviewed。The progress of CaTiO_(3),BaTiO_(3) based piezoelectric ceramics,Sodium potassium Niobate[(K,Na)NbO_(3)]based(KNN based)lead-free piezoelectric ceramics and LiNbO_(3) as bone graft materials are introduced。Biopiezoelectric ceramics have good cytocompatibility and histocompatibility and have the potential to be used as bone substitutes。