摘要
To date,it remains unclear if severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)co-infection exacerbates liver injury in patients with chronic hepatitis B virus(HBV)infection.In this study,we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019(COVID-19)cases,including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19.We found that there were no significant differences for the discharge rate or duration of hospitalization be-tween the two groups.However,inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests.The enhanced liver injury induced by SARS-CoV-2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type.Moreover,the inflammatory response,including abnormal lactate dehydrogenase,D-dimer and interleukin-6 production,may contribute to this injury following SARS-CoV-2 co-infection.Collectively,SARS-CoV-2 and HBV co-infection exacerbates liver function of the pa-tients with COVID-19.
基金
This work was supported by the Major National S&T Program(grant numbers 2017ZX10202203 and 2017ZX10302201)from Sdience&Technology Commission of China,the Emergency Project(grant number cstc2020jscx-fyzx0053)from the Sci-ence&Technology Commission of Chongqing,the Natural Science Foundation Project of CQ CSTC(grant number cstc2020jcyj-msxmX0081)
the Venture and Innovation Sup-port Program for Chongqing Overseas Returnees(grant number cx2019114)
the COVID-19 Emergengy Project(grant number CQMUNCP0207)
the Scientfic Research Staring Foundation of Chongqing Medical University(grant number X9729)from Chongqing Medical University.
