关于脓毒症的发生机制与识别和干预

Pathogenesis,diagnosis,and management for sepsis:update progress and scientific problems

脓毒症是由不同病原体及其毒性因子引起宿主对感染的反应失调,并导致多器官功能障碍。脓毒症发生机制复杂,涉及表观遗传重编程、代谢衰竭、免疫功能障碍、神经-内分泌紊乱、凝血异常、组织或器官衰竭等诸多科学问题。本文旨在了解脓毒症的宿主反应和发病机制,进而根据脓毒症异质性特点,探索精准诊疗的预警标志物和干预靶标,最终降低脓毒症的发病率和病死率。

Sepsis is caused by various pathogens and toxic factors,which can lead to multiple organ dysfunction.The underlying mechanism of sepsis appears to be complex,involving epigenetic reprogramming,metabolic failure,immune dysfunction,neuroendocrine system disorders,coagulation abnormalities,tissue or organ failure,and many other scientific issues.With our deep understanding of the host reaction and development of sepsis,it is of great significance to explore predicative markers and therapeutic targets according to the atypical characteristics of sepsis,thereby contributing to the reduction of morbidity and mortality of sepsis.