从可视化分析看我国重症医学科多重耐药菌研究热点

Visual analysis of research on multidrug-resistant bacteria in intensive care unit in China

目的通过可视化方法,识别我国重症医学科多重耐药菌领域中的研究热点分布、研究前沿以及预测未来的研究方向,分析该研究领域的研究发展过程,为该领域的进一步研究提供参考依据。方法搜集2000至2019年中国知网(CNKI)收录的有关重症医学科多重耐药菌研究的相关文献,借助CiteSpace 5.6.R2软件对关键词进行图谱网络共现,分析该领域研究热点分布;同时利用关键词的突变词图谱,在一定程度上预测未来的研究发展方向。结果最终纳入计量分析的文献共1324篇,2000至2019年重症医学科多重耐药菌研究领域年发文量呈逐步上升趋势,其中2008至2014年呈快速增长(年发文量从34篇增长至124篇)。在研究初期,研究热点关键词以概念性关键词为主,如重症监护病房、感染、病原菌、耐药性等;2008至2014年左右出现涵盖较多方面的密集关键词群,如医院感染、鲍曼不动杆菌、病原菌、抗药性、脉冲场凝胶电泳、护理等,提示该领域的研究在此阶段进入了蓬勃发展期;2015至2019年出现了危险因素、病原菌、抗菌药物、院内感染、耐药基因、同源性等频次较高的关键词,代表着近年来的研究热点。结论我国重症医学科多重耐药菌研究领域总体研究逐步完善,现阶段的研究重点在于同源性分析、多重耐药菌感染等方面,未来会从基因层面进一步探究,以填补该领域的研究空缺,为减少多重耐药菌的出现提供分子生物学依据。

Objective To identify the distribution of research hotspots and frontiers of multidrug-resistant bacteria in intensive care units in China through the method of visualization,and to predict future research directions,analyze the research development process,so as to provide reference basis for further research in this field.Methods Studies related to multidrug-resistant bacteria in intensive care units published in China from 2000 to 2019 by CNKI were reviewed.According to the keywords by CiteSpace 5.6.R2,the co-occurring network was generated to analyze the distribution of research hotspots in this field.Meanwhile,the mutation map of keywords was used to forecast the future research directions to a certain extent.Results A total of 1324 articles were finally included in the quantitative analysis.From 2000 to 2019,the number of publications in the field of multi-drug resistant bacteria in intensive care units showed a gradual increase,of which the number of publications increased rapidly from 2008 to 2014(the number of publications increased from 34 to 124 articles).In the initial stage of research,conceptual keywords appeared,such as intensive care unit,infection,pathogenic bacteria and drug resistance among others.A dense keywords group appeared from 2008 to 2014,which covered several aspects,such as nosocomial infection,Acinetobacter baumannii,pathogenic bacteria,drug resistance,pulsed field gel electrophoresis and nursing etc.,suggesting that research in this field has entered a period of vigorous development.High-frequency keywords,such as risk factors,pathogens,antibiotics,nosocomial infections,drug resistance genes and homology appeared from 2015 to 2019,thus representing the hotspots in recent years.Conclusions The overall research on multidrug-resistant bacteria in intensive care units in China has gradually improved.The current studies focus on homology analysis and multidrug-resistant bacteria infections,among other topics.Further explorations at the genetic level will be conducted to fill the research vacancy in this field and to provide molecular biological basis for reducing the occurrence of multidrug-resistant bacteria in the future.