胆道支架联合^(125)I粒子条治疗恶性梗阻性黄疸的发展及现状

Development and current status of biliary stent combined with ^(125)I seed strand for the treatment of malignant obstructive jaundice

恶性梗阻性黄疸(malignant obstructive jaundice,MOJ)是胆管、胆囊、胰腺及壶腹部晚期恶性肿瘤的常见并发症。近年来,随着科技与影像技术的发展,胆道支架联合^(125)I粒子条置入术已逐渐应用于MOJ的姑息性治疗。胆道支架联合^(125)I粒子条可迅速缓解梗阻性黄疸,降低血清胆红素,改善肝功能,其^(125)I粒子条的放射性又可以杀伤肿瘤组织及抑制胆管内皮细胞增生,降低肿瘤指标,提高支架通畅性,延长患者的生存期。本文就胆道支架联合^(125)I粒子条治疗MOJ的应用作一综述。

Malignant obstructive jaundice(MOJ)is a common complication of advanced malignant tumors of bile duct,gallbladder,pancreas and ampulla.In recent years,with the development of medical technology and imaging technology,biliary stent combined with ^(125)I seed strand has been gradually applied to MOJ palliative treatment.This technique can relieve obstructive jaundice,decrease serum bilirubin and improve liver function.The radioactivity of ^(125)I seed strand can kill tumor tissue,inhibit the proliferation of bile duct endothelial cells,reduce tumor markers,improve the patency of stent,and prolong the survival period of patients.This article reviews the application of biliary stent combined with ^(125)I seed strand in the treatment of MOJ.