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The Nuclear Factor KappaB(NF-kB)signaling in cancer development and immune diseases 被引量:23

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摘要 The nuclear factor kappa B(NF-kB)family of transcription factors plays an essential role as stressors in the cellular environment,and controls the expression of important regula-tory genes such as immunity,inflammation,death,and cell proliferation.NF-kB protein is located in the cytoplasm,and can be activated by various cellular stimuli.There are two path-ways for NF-kB activation,as the canonical and non-canonical pathways,which require com-plex molecular interactions with adapter proteins and phosphorylation and ubiquitinase enzymes.Accordingly,this increases NF-kB translocation in the nucleus and regulates gene expression.In this study,the concepts that emerge in different cellular systems allow the design of NF-kB function in humans.This would not only allow the development for rare dis-eases associated with NF-kB,but would also be used as a source of useful information to elim-inate widespread consequences such as cancer or inflammatory/immune diseases.
出处 《Genes & Diseases》 SCIE 2021年第3期287-297,共11页 基因与疾病(英文)
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