脑卒中后抑郁患者炎症标志物的研究进展

Research Progress of Inflammatory Markers in Patients with Post-stroke Depression

脑卒中后抑郁(PSD)是脑卒中的主要合并症,其病理生理过程与炎症反应有一定联系,包括促炎因子介导的炎症促进过程及抑炎因子介导的炎症抑制过程。炎症反应与抑郁症的发展和维持有关,炎症不仅使神经递质浓度过度升高,还可诱发和加重应激反应。目前有关炎症标志物(白细胞介素、肿瘤坏死因子等)影响PSD发生发展的相关研究逐渐增多,但炎症标志物在PSD发生发展中的具体作用机制尚不明确。对PSD中炎症标志物的深入研究,有助于PSD的早期诊断、合理治疗、疗效评价、风险预测等,对未来PSD的诊治具有积极意义。

Post-stroke depression(PSD)is a major complication of stroke.Its pathophysiological processes are related to inflammatory response,including pro-inflammatory factors mediated inflammatory promotion process and anti-inflammatory factors mediated inflammatory inhibition process.Inflammation is related to the development and maintenance of depression,which not only increases the concentration of neurotransmitters,but also induces and aggravates stress response.At present,there are more and more studies on the effect of inflammatory markers(interleukin,tumor necrosis factor,etc.)on the development of PSD,but the specific mechanism is not clear yet.The in-depth study of inflammatory markers in PSD is helpful to the early diagnosis,reasonable treatment,efficacy evaluation and risk prediction of PSD,and has positive significance for the diagnosis and treatment of PSD in the future.