基于“过咸伤骨”理论探讨高盐摄入与原发性骨质疏松症的相关性

Correlation between High Salt Intake and Primary Osteoporosis Based on Theory of"Oversalted Damaging Bone"

中医理论在揭示原发性骨质疏松症(POP)的病因病机以及指导POP的防治方面均具有独特优势。《内经》中的“咸入肾,肾主骨,过咸伤骨”理论准确地阐释了中医五味之咸的过多摄入导致骨骼失养的病理进程。该理论亦与现代医学研究中高盐摄入可直接或间接引起骨量减少,最终导致POP的发生、发展高度契合。但目前现代医学对高盐摄入与POP的相关性及其发病机制的认识尚不统一。深入研究饮食中高盐摄入与POP的相关性可为POP的防治以及相关临床研究提供理论依据及参考,这也是目前研究中亟待解决的问题。

Traditional Chinese medicine theory has unique advantages in revealing the etiology and pathogenesis of primary osteoporosis(POP)and guiding the prevention and treatment of POP.The theory of"salt enters the kidneys,kidneys govern bones,and oversalted damages bone"in Neijing accurately explains the pathological process of skeletal dystrophy caused by excessive intake of salt of the five flavors in Chinese medicine.This theory also has a high degree of compatibility with modern medical research that high salt intake can directly or indirectly cause bone loss,and ultimately lead to the occurrence and development of the POP.However,the understanding of the correlation between high salt intake and the POP and its pathogenesis in modern medical research is still not unified.Further research on the correlation between high salt intake in diet and the POP can provide theoretical basis and reference for the prevention and treatment of the POP and related clinical research,which is also an urgent problem in current research.