反复呼吸道感染儿童维生素A缺乏状况与炎症因子、免疫功能指标相关性分析

Correlation analysis of vitamin A deficiency with inflammatory factors and immune function indexes in children with RRTI

目的:分析儿童反复呼吸道感染(RRTI)患者维生素A缺乏状况与炎症因子、免疫功能指标的相关性。方法:选取100例RRTI患儿作为研究组,另选取同期参加体检的100例健康儿童作为对照组。检测并记录两组儿童炎症因子[白介素-1(IL-1)、白介素-6(IL-6)]水平、维生素A水平、免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]水平,并采用Pearson相关性分析法作维生素A与炎症因子和免疫功能指标的相关性分析。结果:研究组儿童炎症因子IL-1、IL-6、维生素A水平均明显低于对照组,差异有统计学意义(P<0.05)。研究组儿童免疫功能指标IgA、IgG、IgM均明显低于对照组,差异有统计学意义(P<0.05)。维生素A与炎症因子IL-1(r=0.414,P<0.05)、IL-6(r=0.474,P<0.05)、免疫功能指标IgA(r=0.481,P<0.05)、IgG(r=0.391,P<0.05)、IgM(r=0.386,P<0.05)均呈正相关。结论:儿童反复呼吸道感染患者维生素A缺乏状况与炎症因子(IL-1、IL-6)、免疫功能指标(IgA、IgG、IgM)均具有相关性,可作为患者维生素A缺乏的判断指标。

Objective:To analyze the relationship between vitamin A deficiency and inflammatory factors and immune function indexes in children with recurrent respiratory tract infection(RRTI).Methods:100 cases of children with RRTI were selected as the study group,and 100 cases of healthy children during the same period were selected as the control group.The levels of inflammatory factors(IL-1,IL-6),vitamin A and immune function indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)]in the two groups were detected and recorded.Pearson correlation analysis was used to analyze the correlation between vitamin A and inflammatory factors and immune function indexes.Results:The levels of IL-1,IL-6 and vitamin A in the study group were significantly lower than those in the control group(all P<0.05).The levels of IgA,IgG and IgM of the study group were significantly lower than those of the control group(all P<0.05).Vitamin A was positively correlated with IL-1,IL-6,IgA,IgG and IgM(r=0.414,0.474,0.481,0.391,0.386,all P<0.05).Conclusion:Vitamin A deficiency in children with RRTI is correlated with inflammatory factors(IL-1,IL-6)and immune function indexes(IgA,IgG,IgM),which can be used as judgment index of vitamin A deficiency.