摘要
原发性膜性肾病(PMN)是儿童期罕见的一种肾病病理类型,临床表现为肾病综合征或无症状蛋白尿,常伴镜下血尿、氮质血症或高血压;病理特征为肾小球基底膜增厚伴或不伴钉突形成,颗粒状IgG和补体C3沿肾小球毛细血管襻沉积。近年来儿童PMN发病率升高引起国内外学者的关注,但其发病机制尚不清楚,且无统一的治疗方案。文章综述近年PMN的研究现状。
Primary membranous nephropathy(PMN)is a rare pathological type of nephropathy in childhood.The clinical manifestations are nephrotic syndrome or asymptomatic proteinuria,often accompanied by microscopic hematuria,azotemia or hypertension.The pathological features are glomerular basement membrane thickening with or without spike formation and deposits of granular IgG and complement C 3 along the glomerular capillary loops.In recent years,the incidence of PMN in children has increased,but the pathogenesis of PMN in children is still unclear,and there is no uniform therapeutic protocol.This article summarizes the research status of PMN in recent years.
作者
王忍(综述)
高春林
夏正坤(审校)
WANG Ren;GAO Chunlin;XIA Zhengkun(Department of Pediatrics,Jinling Hospital,Nanjing Medical University,Nanjing 210002,Jiangsu,China;Department of Pediatrics,Jinling Hospital,The First School of Clinical Medicine,Southern Medical University,Nanjing 210002,Jiangsu,China;不详)
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2021年第7期549-552,共4页
Journal of Clinical Pediatrics
基金
江苏省科学技术厅项目(No.BE2017719)
江苏省卫生和计划生育委员会项目(No.CXTDA2017022)。
关键词
膜性肾病
原发性
儿童
membranous nephropathy
primary
child