保乳手术与改良根治术治疗早期乳腺癌的疗效对比

Comparison of the efficacy of breast conserving surgery and modified radical mastectomy in the treatment of early breast cancer

目的对比早期乳腺癌患者运用保乳手术与改良根治术治疗的临床价值。方法选取青岛妇女儿童医院(城阳院区)2017年1月至2019年12月收治的130例早期乳腺癌患者,按照随机数字表法分为观察组和对照组,各65例。观察组患者进行保乳手术治疗,对照组进行改良根治术治疗。对比两组患者术中情况、治疗效果、并发症和症状改善情况。结果观察组患者术中出血量为(37.52±8.41)mL,显著低于对照组的(64.25±10.32)mL,差异有统计学意义(t=16.188,P<0.05);观察组患者手术时间、住院时间分别为(52.31±11.02)min、(10.26±1.54)d均短于对照组(87.52±14.42)min、(16.95±1.85)d,(t=15.641、22.407,P<0.05);观察组患者治疗总有效率为96.92%,显著高于对照组的78.46%(χ^(2)=9.630,P<0.05),观察组患者并发症发生率为6.15%,显著低于对照组的18.46%(χ^(2)=4.561,P<0.05);且治疗后,观察组患者各项生存指标评分优于对照组(P<0.05)。结论与改良根治术相比,对早期乳腺癌患者运用保乳手术治疗,能够减少患者术中出血量,缩短手术时间、住院时间,提高治疗效果,降低并发症发生率,显著改善和缓解患者的临床症状,具有较高的治疗有效性和安全性。

Objective To compare the clinical value of breast conserving surgery and modified radical mastectomy in early breast cancer patients.Methods A selection of 130 early breast cancer patients admitted to Qingdao Women and Children's Hospital(Chengyang District)from January 2017 to December 2019 were divided into observation group and control group,with 65 cases in each according to the random number table method.The observation group was treated with breast-conserving surgery,the control group was treated with modified radical mastectomy.The intraoperative conditions,treatment effects,complications and symptom improvement of the two groups were compared.Results The intraoperative blood loss in the observation group(37.52±8.41)mL was significantly lower than that in the control group(64.25±10.32)mL,the difference was statistically significant(t=16.188,P<0.05).The operation time and hospitalization time of the observation group were(52.31±11.02)min and(10.26±1.54)d,respectively,shorter than those of the control group(87.52±14.42)min and(16.95±1.85)d,(t=15.641,22.407,P<0.05).The total effective rate of 96.92%in observation group was significantly higher than that of 78.46%in control group(χ2=9.630,P<0.05),the complication rate of observation group was 6.15%significantly lower than that of control group 18.46%,(χ2=4.561,P<0.05).After treatment,the scores of survival indexes in the observation group were better than those in the control group(P<0.05).Conclusion Compared with modified radical mastectomy,the use of breast-conserving surgery for early breast cancer patients can reduce intraoperative blood loss,shorten operation time and hospital stay,improve treatment effect,reduce the incidence of complications,and significantly improve and relieve the clinical conditions of patients symptoms,with high therapeutic effectiveness and safety.