"标本配穴"针灸结合甲钴胺对老年糖尿病周围神经病变患者糖脂代谢、炎性细胞因子和受损神经传导速度的影响

The Effect of"Specimen Matching Points"Acupuncture Combine with Mecobalamin on Glycolipid Metabolism,Inflammatory Cytokines and Damaged Nerve Conduction Velocity in Elderly Diabetic Peripheral Neuropathy Patients

目的:探讨"标本配穴"针灸结合甲钴胺对老年糖尿病周围神经病变(DPN)患者糖脂代谢、炎性细胞因子和受损神经传导速度的影响。方法:选取2018年3月~2019年12月期间我院收治的93例老年DPN患者,按照随机数字表法将患者分为研究组(n=47)、对照组(n=46),对照组患者予以甲钴胺治疗,研究组在对照组的基础上联合"标本配穴"针灸治疗,比较两组疗效、糖脂代谢、炎性细胞因子、受损神经传导速度及不良反应。结果:研究组治疗4周后的临床总有效率87.23%(41/47)高于对照组69.57%(32/46)(P<0.05)。两组治疗4周后空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、糖化血红蛋白(HbAlc)均下降,且研究组低于对照组(P<0.05)。两组治疗4周后白介素-6(IL-6)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)均下降,且研究组低于对照组(P<0.05)。两组治疗4周后腓总神经运动神经传导速度(MCV)、正中神经MCV、腓总神经感觉神经传导速度(SCV)、正中神经SCV均升高,且研究组高于对照组(P<0.05)。两组均未见明显不良反应发生。结论:"标本配穴"针灸结合甲钴胺治疗老年DPN患者疗效确切,可改善患者糖脂代谢、炎性细胞因子和受损神经传导速度,安全可靠。

Objective:To investigate the effect of"specimen matching points"acupuncture combine with Mecobalamin on glycolipid metabolism,inflammatory cytokines and damaged nerve conduction velocity in elderly diabetic peripheral neuropathy(DPN)patients.Methods:93 elderly DPN patients who were admitted to our hospital from March 2018 to December 2019 were selected,the patients were divided into control group(n=46)and study group(n=47)according to the method of random number table.Patients in the control group were treated with Mecobalamin,the study group was treated with"sample matching point"acupuncture on the basis of the control group,the clinical effective,glycolipid metabolism,inflammatory cytokines,damaged nerve conduction velocity and adverse reactions were compared between the two groups.Results:The total clinical effective rate of the study group after 4 weeks was 87.23%(41/47)higher than 69.57%(32/46)of the control group(P<0.05).Fasting blood glucose(FPG),triglyceride(TG),total cholesterol(TC),glycosylated hemoglobin(HbAlc)were all decreased in the two groups at 4weeks after treatment,and the study group were lower than those in the control group(P<0.05).Interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)were all decreased in the two groups at 4weeks after treatment,and the study group were lower than those in the control group(P<0.05).Motor nerve conduction velocity of common peroneal nerve(MCV),Median nerve MCV,Sensory nerve conduction velocity of common peroneal nerve(SCV),median nerve SCV of median nerve were all increased in the two groups after 4 weeks of treatment,and those in the study group were higher than those in the control group(P<0.05).No obvious adverse reactions were found in both groups.Conclusion:"specimen matching points"acupuncture combined with Mecobalamin can effectively improve glucose and lipid metabolism,inflammatory cytokines and damaged nerve conduction velocity in elderly DPN patients without increasing the incidence of adverse reactions.