痰热清注射液联合头孢他啶对心力衰竭合并肺部感染患者的疗效探讨

Tanreqing Injection Combined with Ceftazidime in the Treatment of Heart Failure Complicated with Pulmonary Infection

目的:研究痰热清注射液联合头孢他啶对心力衰竭合并肺部感染患者的疗效。方法:选择2019年1月~2019年12月我院收治的81例心力衰竭合并肺部感染患者,随机奇偶法分为两组。均给予抗感染、抗心律失常、吸氧、利尿、扩血管、平喘和强心等治疗。对照组静脉滴注头孢他啶,每天两次,每次2.0 g;观察组在头孢他啶的基础上加用痰热清注射液,每天静脉滴注1次,每次20 mL。检测两组的血清C反应蛋白(C-reactive protein,CRP)、白细胞介素-1β(interleukin-1β,IL-1β)、降钙素原(procalcitonin,PCT)和白细胞介素-8(interleukin-8,IL-8)水平、左心室舒张期末内径(Left ventricular end diastolic diameter,LVEDD)、6 min步行试验(6 min walking test,6MWT)、左心室射血分数(Left ventricular ejection fraction,LVEF)。结果:观察组的有效率为95.00%,明显高于对照组的73.17%(P<0.05);治疗前,两组的血清CRP、IL-1β、PCT和IL-8水平无差异(P>0.05),治疗后,两组的上述指标均明显降低(P<0.05),且观察组更低(P<0.05);治疗前,两组的LVEDD、6MWT和LVEF无差异(P>0.05),治疗后,两组的上述指标明显改善(P<0.05),观察组更为明显(P<0.05)。结论:痰热清注射液联合头孢他啶对心力衰竭合并肺部感染患者有比较显著的疗效,能明显降低其血清炎症指标,有效控制感染,改善心功能,值得进行推广。

Objective:To investigate the effect of Tanreqing injection combined with ceftazidime in the treatment of heart failure complicated with pulmonary infection.Methods:Selected 81 cases of patients with heart failure complicated with pulmonary infection who were treated in our hospital from January 2019 to December 2019,random parity method is divided into two groups.All were given anti-infection,anti-arrhythmia,oxygen inhalation,diuretic,vasodilator,asthma,and cardiotonic therapy.The control group was intravenously infused with ceftazidime twice a day,2.0 g each time.The observation group was added with Tanreqing injection on the basis of ceftazidime,and was intravenously infused once a day,20 mL each time.Detection of serum CRP,IL-1β,PCT,and IL-8 level,LVEDD,6MWT,and LVEF.Results:The effective rate of the observation group was 95.00%,which was significantly higher than that of the control group 73.17%(P<0.05).Before treatment,there was no difference in serum CRP,IL-1β,PCT and IL-8 levels between the two groups(P>0.05).After treatment,the above indexes of the two groups were significantly reduced(P<0.05),and the observation group was lower(P<0.05).Before treatment,there was no difference in LVEDD,6MWT and LVEF between the two groups(P>0.05).After treatment,The above indicators of the two groups were significantly improved(P<0.05),the observation group was more obvious(P<0.05).Conclusion:Tanreqing injection combined with ceftazidime has a significant effect on patients with heart failure complicated with pulmonary infection.It can significantly reduce the serum inflammatory index,effectively control infection and improve cardiac function,which is worthy of promotion.