吡嗪酰胺联合左氧氟沙星治疗耐多药肺结核的效果观察

Observation on the Effect of Pyrazinamide Combined with Levofloxacin in the Treatment of Multidrug-Resistant Pulmonary Tuberculosis

目的探讨吡嗪酰胺联合左氧氟沙星治疗耐多药肺结核(MDR-TB)的临床效果。方法选择2018年1月至2020年1月我院收治的MDR-TB患者180例,随机分为两组各90例。在常规抗结核治疗基础上,对照组给予吡嗪酰胺治疗,观察组给予吡嗪酰胺联合左氧氟沙星治疗。比较两组的治疗效果、治疗前后的肺功能指标及不良反应。结果观察组的治疗总有效率为92.22%,显著高于对照组的74.44%(P<0.05)。治疗后,两组的FEV1、PEF均显著高于治疗前,且观察组的FEV1、PEF均显著高于对照组(P<0.05)。观察组的不良反应发生率为7.78%,显著低于对照组的18.89%(P<0.05)。结论吡嗪酰胺联合左氧氟沙星治疗MDR-TB的效果确切,可显著改善患者的肺功能,且安全性较高。

Objective To explore the clinical effect of pyrazinamide combined with levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis(MDR-TB).Methods 180 cases of MDR-TB patients admitted to our hospital from January 2018 to January 2020 were selected and randomly divided into two groups,with 90 cases in each group.On the basis of conventional anti-tuberculosis treatment,the control group was treated with pyrazinamide,and the observation group was treated with pyrazinamide combined with levofloxacin.The therapeutic effect,the pulmonary function indicators before and after treatment and the adverse reactions were compared between two groups.Results The total effective rate of treatment of observation group was 92.22%,significantly higher than 74.44%of control group(P<0.05).After treatment,FEV1 and PEF of both groups were significantly higher than those before treatment,and FEV1 and PEF of observation group were significantly higher than those of control group(P<0.05).The incidence of adverse reactions of observation group was 7.78%,significantly lower than 18.89%of control group(P<0.05).Conclusions Pyrazinamide combined with levofloxacin in the treatment of MDR-TB has exact effect and high safety,and can significantly improve the pulmonary function of patients.