胺碘酮治疗急性心肌梗死合并心房颤动的临床效果及安全性分析

Analysis on theClinical Effect and Safety of Amiodarone in the Treatment of Acute Myocardial Infarction Complicated with Atrial Fibrillation

目的探讨胺碘酮治疗急性心肌梗死合并心房颤动的临床效果及安全性。方法选取2017年5月至2018年5月我院收治的94例急性心肌梗死合并心房颤动患者,随机分为两组各47例。对照组采用心律平治疗,观察组采用胺碘酮治疗。比较两组的临床疗效、治疗后的心率、P-R间期、校正QT间期(QTc)、左室射血分数(LVEF)以及不良反应发生率。结果观察组的总有效率为93.62%,显著高于对照组的74.47%,差异有统计学意义(P<0.05)。治疗后,观察组的心率、P-R间期、QTc、LVEF均显著高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率为8.51%,显著低于对照组的29.79%,差异有统计学意义(P<0.05)。结论胺碘酮治疗急性心肌梗死合并心房颤动患者能够取得良好的临床效果,有效减少房颤,改善心功能,降低不良反应发生率,安全性较高。

Objective To explore the clinical effect and safety of amiodarone in the treatment of acute myocardial infarction complicated with atrial fibrillation.Methods 94 patients with acute myocardial infarction complicated with atrial fibrillation admitted to our hospital from May 2017 to May 2018 were selected and randomly divided into two groups,with 47 patients in each group.The control group was treated with propafenone,and the observation group was treated with amiodarone.The clinical efficacy,and the heart rate,P-R interval,corrected QT interval(QTc)and left ventricular ejection fraction(LVEF)after treatment,and the incidence of adverse reactions were compared between two groups.Results The total effective rate of observation group was 93.62%,significantly higher than 74.47%of control group,with statistically significant difference(P<0.05).After treatment,the heart rate,P-R interval,QTc and LVEF of observation group were significantly higher than those of control group,with statistically significant differences(P<0.05).The incidence of adverse reactions of observation group was 8.51%,significantly lower than 29.79%of control group,with statistically significant difference(P<0.05).Conclusions Amiodarone in the treatment of acute myocardial infarction complicated with atrial fibrillation can achieve good clinical effect,effectively reduce atrial fibrillation,improve cardiac function,and reduce the incidence of adverse reactions,with high safety.