内镜下猪离体大肠黏膜缝合术的实验研究

Endoscopic hand-suturing of mucosal defect of ex vivo porcine colon: an experimental study

目的设计并评价一套新型缝合器械在猪离体大肠黏膜剥离创面缝合术中应用的可行性。方法采用4条健康成年家猪的新鲜大肠,随机分为2组,每组各2条。每条大肠每隔10 cm制作一个直径约3 cm的黏膜剥离创面,共10处。在肠镜下,两组均使用新型缝合器械缝合剥离的创面,记录每处手术完成时间。结果全组均完成预定实验。两组手术时间相仿,差异无统计学意义[(19.4±2.5)min vs(19.1±2.3)min,t=0.30,P>0.05]。结论肠镜下使用新型缝合器械可缝合黏膜创面,具有进出针便捷、手术时间短、操作方便等优点,器械细节及加工工艺有待进一步改进。

Objective To design and evaluate the feasibility of a new set of suture instruments in the endoscopic hand-suturing of the mucosal defect of the ex vivo porcine colon.Methods Approximately 3 cm colonic mucosal resections were created every 10 cm(10 places in total)in four ex vivo porcine colons divided into two groups randomly(2 ex vivo porcine colons for each)that were closed with an absorbable barbed suture,a through-the-scope needle holder,and vascular forceps,respectively.The procedure time were recorded.Results Both groups completed the scheduled operation.The experimental group was similar to the control group in operative time[(19.4±2.5)min vs(19.1±2.3)min,t=0.30,P>0.05].Conclusion The new set of suture instruments in the endoscopic hand-suturing of the mucosal defect of the ex vivo porcine colon is feasible,which has the advantages of convenient needle in and out,short operative time,and convenient operation,but the device details and processing technology need further improvement.