肝吸虫引发胆管细胞癌发病机制的研究进展

Research progress in the pathogenesis of cholangiocarcinoma caused by liver flukes

肝吸虫病是一种危害性极大的食源性寄生虫病。全世界感染肝吸虫的人数大约有3500万,约有11亿人存在感染风险。长期肝吸虫感染引起最严重的并发症是胆管细胞癌(CCA),世界卫生组织国际癌症研究署已经将肝吸虫列为CCA的Ⅰ类致癌性病原体。近年来,有许多学者对肝吸虫感染的致癌机制做了相应的临床及实验研究,但至今其致癌机制尚未明晰。该文就肝吸虫引发CCA的发病机制作一综述。

Clonorchiasis is a kind of food-borne parasitic diseases with great harmfulness.There are about 35 million people infected with liver flukes in the world,and about 1.1 billion people are at risk of infection.Cholangiocarcinoma(CCA)is the most serious complication caused by long-term infection of liver flukes.Therefore,World Health Organization International Cancer Research Agency has listed liver flukes as a classⅠcarcinogenic pathogen of CCA.In recent years,many scholars have done the corresponding clinical and experimental studies on the carcinogenic mechanisms of liver flukes infection,but so far their carcinogenic mechanisms are not very clear.In this paper,we review the pathogenesis of CCA caused by liver flukes.