摘要
开发高效、低毒、低残留的绿色农药是农药研发的发展趋势,其中微生物源农药抗生素占据了重要地位。随着基因组学、代谢工程和高通量筛选等技术的发展,新型微生物源农用抗生素的研究进入了新的阶段。文中简要总结了近10年来研发的新型微生物源农用抗生素的种类、农用抗生素产生菌株的高产育种与发酵研究策略等,为未来农用抗生素的研发提供参考。
The development of high-efficiency,low-toxicity,and low-residue green pesticides is the main trend of pesticide research,and the microbial-derived antibiotics are one of the essential parts of green pesticides and play a significant role in agriculture.With the development of microbial genomics technology,metabolic engineering,high-throughput screening and other technologies,the research on new microbial-derived antibiotics has entered a new stage in agriculture.Here we briefly summarize the types of new microbial-derived antibiotics developed in agriculture over the past decade.We also introduce the research strategies for high-yield breeding and fermentation of antibiotic-producing strains in agriculture.This review may provide references for the future development of agricultural antibiotics.
作者
崔佳佳
张雪洪
Jiajia Cui;Xuehong Zhang(State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2021年第3期1032-1041,共10页
Chinese Journal of Biotechnology
基金
国家自然科学基金(No.31670033)
国家重点研发计划(No.2019YFA0904300)资助。
关键词
微生物
农用抗生素
高产菌株
育种
microorganism
agricultural antibiotics
high-producing strain
breeding
