奥曲肽+乌司他丁治疗重症急性胰腺炎的效果和并发症发生率分析

Analysis of effect and complication rate of octreotide and urinastatin in the treatment of severe acute pancreatitis

目的探析重症急性胰腺炎采取奥曲肽+乌司他丁治疗的临床效果。方法 70例重症急性胰腺炎患者,以双盲法分为常规组(34例)和治疗组(36例)。常规组在常规治疗基础上加用奥曲肽治疗,治疗组在常规组基础上采用乌司他丁治疗。比较两组临床疗效,并发症发生情况、血清炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、症状消失时间、胃肠道功能恢复时间及住院时间。结果治疗组总有效率97.22%高于常规组的79.41%,差异有统计学意义(P<0.05)。治疗后,治疗组CRP(6.22±1.55)mg/L、IL-6(25.14±7.23)pg/ml及TNF-α(23.55±2.40)pg/ml低于常规组的(11.27±2.11)mg/L、(33.11±8.03)pg/ml、(36.71±2.62)pg/ml,差异有统计学意义(P<0.05)。治疗组症状消失时间、胃肠道功能恢复时间及住院时间短于常规组,差异有统计学意义(P<0.05)。两组并发症发生率比较差异无统计学意义(χ^(2)=0.860, P=0.354>0.05)。结论重症急性胰腺炎采取奥曲肽+乌司他丁治疗效果令人满意,可改善患者症状,削弱炎症因子表达活性,无显著并发症,安全性高,值得临床推广。

Objective To discuss and analyze the clinical effect of octreotide and urinastatin in the treatment of severe acute pancreatitis.Methods A total of 70 patients with severe acute pancreatitis were divided into conventional group(34 cases)and treatment group(36 cases)according to double-blind method.The conventional group was treated with octreotide based on conventional therapy,and the treatment group was treated with urinastatin based on the conventional group.The clinical efficacy,occurrence of complications,serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels,symptoms disappearance time,recovery time of gastrointestinal function,and hospitalization time were compared between the two groups.Results The total effective rate 97.22%of the treatment group was higher than 79.41%of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the CRP(6.22±1.55)mg/L,IL-6(25.14±7.23)pg/ml and TNF-α(23.55±2.40)pg/ml of the treatment group were lower than(11.27±2.11)mg/L,(33.11±8.03)pg/ml and(36.71±2.62)pg/ml of the conventional group,and the difference was statistically significant(P<0.05).The symptoms disappearance time,recovery time of gastrointestinal function,and hospitalization time of the treatment group were shorter than those of conventional group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of complications between the two groups(χ^(2)=0.860,P=0.354>0.05).Conclusion Combination of octreotide and urinastatin shows satisfactory effect on patients with severe acute pancreatitis,which can improve the symptoms of patients,weaken the expression of inflammatory factors without significant complications.It has high safety,and is worthy of clinical promotion.