不同剂量奥美拉唑治疗胃溃疡合并急性出血的有效性分析

Effectiveness analysis of different doses of omeprazole in the treatment of acute gastric ulcer bleeding

目的评价不同剂量奥美拉唑对胃溃疡合并急性出血患者的临床治疗效果。方法 106例胃溃疡合并急性出血患者,随机分为常规组与研究组,各53例。两组患者均进行常规基础治疗,常规组患者入院后予以常规剂量奥美拉唑进行治疗,研究组患者入院后予以大剂量奥美拉唑进行治疗。对比两组患者治疗72 h、7 d临床疗效,治疗后胃溃疡修复情况,止血时间、溃疡愈合时间及住院天数。结果研究组治疗72 h的总有效率96.23%明显高于常规组的75.47%,差异具有统计学意义(P<0.05);研究组患者治疗7 d的总有效率100.00%显著高于常规组的86.79%,差异具有统计学意义(P<0.05)。研究组患者治疗后7 d胃溃疡修复率96.23%显著高于常规组的77.36%,差异具有统计学意义(P<0.05)。研究组患者止血时间、溃疡愈合时间及住院天数均显著短于常规组,差异具有统计学意义(P<0.05)。结论胃溃疡合并急性出血患者采取大剂量奥美拉唑治疗效果明确,患者出血症状能得到更有效控制,总住院时间短,治疗后患者不良反应率不增加,提示该治疗方案的有效性与安全性,值得临床推广。

Objective To evaluate the clinical effect of different doses of omeprazole in the treatment of acute gastric ulcer bleeding.Methods A total of 106 patients with acute gastric ulcer bleeding were randomly divided into conventional group and research group,with 53 cases in each group.Both groups received conventional basic treatment.The conventional group was treated with regular doses of omeprazole after admission,and the research group was treated with high doses of omeprazole after admission.The clinical efficacy after 72 h and 7 d of treatment,gastric ulcer repair after treatment,hemostasis time,ulcer healing time and hospitalization time were compared between the two groups.Results After 72 h of treatment,the total effective rate 96.23%of the research group was obviously higher than 75.47%of conventional group,and the difference was statistically significant(P<0.05).After 7 d of treatment,the total effective rate 100.00%of the research group was significantly higher than 86.79%of conventional group,and the difference was statistically significant(P<0.05).After 7 d of treatment,the repair rate of gastric ulcer 96.23%of the research group was significantly higher than 77.36%of conventional group,and the difference was statistically significant(P<0.05).The hemostasis time,ulcer healing time and hospitalization time of the research group were significantly shorter than those of conventional group,and the difference was statistically significant(P<0.05).Conclusion High dose of omeprazole has definite effect on patients with acute gastric ulcer bleeding,which can effectively control the bleeding symptoms,shorten hospitalization time without increase of adverse reaction rate after treatment.It is suggested that the treatment plan is effective and safe,and is worthy of clinical promotion.