摘要
目的观察坤泰胶囊对育龄期患者早期卵巢储备功能降低(DOR)的治疗效果。方法确诊为早期DOR育龄期患者45例,予坤泰胶囊连续治疗3月,分析就诊原因、不同治疗时期的月经周期、经量及经期改善效果以及治疗前后相关指标[卵泡刺激素(FSH)、抗穆勒氏激素(AMH)、窦卵泡计数(AFC)]的变化。结果就诊原因为月经问题的患者共31例(68.9%),其中经量减少占比为54.8%、周期改变占比25.8%、停经占比19.4%,孕前检查发现的患者共9例(20.00%),其中伴有月经问题占比55.5%、无明显月经问题占比44.4%;不孕患者为5例(11.1%),其中伴有月经问题占比60.0%、无明显月经问题占比40.0%。除不孕及孕前检查无明显月经问题者,共36例,治疗1个月后总有效率为5.6%,治疗后2个月,总有效率为61.1%,治疗后3个月,总有效率可高达91.7%。FSH随着用药的时间延长呈动态下降趋势、AMH呈动态上升趋势,治疗后2、3个月患者的FSH(11.65±1.62)、(9.87±1.50)IU/L均低于治疗前的(13.16±1.82)IU/L,差异具有统计学意义(P<0.05)。20~29岁、30~35岁患者治疗后3个月后AMH水水平分别为(3.80±0.26)、(2.29±0.68)mg/L均高于治疗前的(3.07±0.48)、(1.67±0.71)mg/L,所有患者治疗后3个月的AFC(6.13±0.64)个高于治疗前的(5.0±0.85)个差异均具有统计学意义(P<0.05)。结论对早期DOR患者,即使无任何临床症状,也需要及时干预,单用坤泰胶囊绝大部分可以缓解和逆转早期DOR的临床症状及生化指标,用药需要足疗程。
Objective To observe the therapeutic effect of Kuntai capsule on patients of childbearing age with early diminished ovarian reserve(DOR).Methods 45 patients with early DOR of childbearing age were treated with Kuntai capsules for 3 months.The causes of treatment,menstrual cycle,menstrual volume and menstrual improvement effect in different treatment periods,and the changes of related indexes[follicle stimulating hormone(FSH),anti-Muller hormone(AMH),antral follicle count(AFC)]before and after treatment were analyzed.Results A total of 31 patients(68.9%)were diagnosed with menstrual problems,of which 54.8%had decreased menstrual volume,25.8%had cycle change and 19.4%had amenorrhea.A total of 9 patients(20.00%)were found in pre-pregnancy examinations,of which 55.5%had menstrual problems and 44.4%had no obvious menstrual problems;5 cases(11.1%)were infertile patients,of which menstrual problems accounted for 60.0%,no obvious menstrual problems accounted for 40.0%.There were 36 cases of infertility and no obvious menstrual problems in pre-pregnancy examinations.the total effective rate was 5.6%after 1 month of treatment,61.1%after 2 months of treatment,and 91.7%after 3 months of treatment.FSH showed a dynamic downward trend and AMH showed a dynamic upward trend with the extension of the medication time.The FSH(11.65±1.62)and(9.87±1.50)IU/L of the patients after 2 and 3 months of treatment were lower than the(13.16±1.82)IU/L before treatment,and the difference was statistically significant(P<0.05).For patients aged 20-29 and 30-35 years old,the AMH levels after 3 months of treatment were(3.80±0.26)and(2.29±0.68)mg/L respectively,which were higher than those before treatment(3.07±0.48)and(1.67±0.71)mg/L;the AFC(6.13±0.64)pieces of all patients 3 months after treatment was higher than that of(5.0±0.85)pieces before treatment.All the differences was statistically significant(P<0.05).Conclusion For patients with early dor,even without any clinical symptoms,timely intervention is also needed.Kuntai Capsule can relieve and reverse most of the clinical symptoms and biochemical indicators of early DOR,and the medication requires a full course of treatment.
作者
柳肃芬
LIU Su-fen(Department of Gynecology,Aviation General Hospital,Beijing 100012,China)
出处
《中国现代药物应用》
2021年第12期165-168,共4页
Chinese Journal of Modern Drug Application
关键词
早期卵巢储备功能降低
育龄期
坤泰胶囊
促卵泡生成素
窦卵泡数
Early diminished ovarian reserve
Childbearing age
Kuntai capsule
Follicle stimulating hormone
Number of antral follicles