实体器官移植与弓形虫病

Solid organ transplantation and toxoplasmosis

免疫功能正常的人感染刚地弓形虫(简称弓形虫)后通常是无症状的,但免疫功能低下者感染可能出现严重的临床症状,甚至导致致命的后果。由于器官移植者实体移植器官的多样性、免疫抑制程度的差异性以及弓形虫病发病率相对较低等特点,临床上对器官移植受者弓形虫感染的风险认识不足。因此,本文就实体器官移植受者弓形虫病的临床表现、发病机制、诊断、预防和治疗作一综述,旨在为临床上实体器官移植后的弓形虫病诊治提供参考。

Toxoplasma gondii infection in immunocompetent people is often asymptomatic,but may lead to severe clinical symptoms in immunocompromised patients,even with fatal consequences.Due to the diversity of solid organ transplants,the degrees of immunosuppression,and the relatively low incidence of toxoplasmosis among organ transplant recipients,the clinical risk of T.gondii infection in organ transplant patients remains poorly understood.Therefore,this paper reviews the clinical manifestations,pathogenesis,diagnosis,prevention,and treatment of toxoplasmosis in solid organ transplant recipients,in order to provide reference for clinical diagnosis and treatment of toxoplasmosis after solid organ transplantation.