氨甲环酸在重庆市4家三级甲等医院骨科住院患者中的应用分析

Application Analysis of Tranexamic Acid in the Orthopedic Inpatients from 4 Third-grade Class-A Hospitals in Chongqing

目的:了解氨甲环酸在骨科住院患者中的应用现状及趋势,为临床合理用药提供参考。方法:对重庆市4家三级甲等医院骨科的3个亚科室(关节外科、脊柱外科、创伤骨科)2017-2020年氨甲环酸的使用量、氨甲环酸使用患者的骨科疾病种类分布以及氨甲环酸使用方法等数据进行分析。结果:4年期间骨科氨甲环酸总使用量逐年递增,增幅为6.2%~52.2%,各科室使用量亦逐年递增;2017-2019年关节外科使用量占比最大(分别为59.2%、53.5%、47.2%),2020年创伤骨科使用量占比最大(39.2%)。整体而言,氨甲环酸在不同种类骨科疾病患者中的使用量占比排前4位的依次为关节置换(25.5%~29.6%)、髋部骨折(19.3%~23.6%)、骨干骨折(13.5%~18.6%)以及骨盆髋臼骨折(8.2%~14.0%);各年度脊柱外科、关节外科以及创伤骨科的氨甲环酸使用方法始终以单纯静脉给药为主(占比分别为55.1%~81.0%、46.9%~77.1%、49.3%~73.3%、44.9%~71.5%)。结论:氨甲环酸在骨科住院患者中的使用量呈明显的逐年增长趋势,且以关节外科、创伤骨科使用为主导;其使用方法仍以单纯静脉给药为主,较为安全可靠。

OBJECTIVE:To investigate the application and trend of tranexamic acid in the orthopedic inpatient,and to provide reference for rational drug use.METHODS:The consumption of tranexamic acid,the distribution of orthopedics diseases using tranexamic acid and route of administration were analyzed in 3 sub-departments(joint surgery department,spinal surgery department,orthopedic trauma department)from 4 third-grade class-A hospitals of Chongqing during 2017 to 2020.RESULTS:The total consumption of tranexamic acid used in orthopaedic department had increased year by year in the past 4 years,with increase of 6.2%-52.2%,and the consumption of tranexamic acid in various departments also increased year by year;from 2017 to 2019,joint surgery department accounted for the largest proportion(59.2%,53.5%,47.2%)to use tranexamic acid,and orthopedic trauma department accounted for the largest proportion(39.2%)in 2020.On the whole,top 4 orthopedic diseases in the list of the consumption of tranexamic acid were joint replacement(25.5%-29.6%),hip fracture(19.3%-23.6%),diaphysis fracture(13.5%-18.6%)and pelvic and acetabular fracture(8.2%-14.0%).The route of administration for tranexamic acid in spinal surgery department,joint surgery department and orthopedic trauma department was mainly intravenous application every year(accounting for 55.1%-81.0%,46.9%-77.1%,49.3%-73.3%,44.9%-71.5%).CONCLUSIONS:The consumption of tranexamic acid in orthopedic inpatients is increased year by year,and is dominated by joint surgery department and orthopedic trauma department.The route of tranexamic acid is still mainly intravenous administration,which is safe and reliable.