摘要肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一种以运动神经元丢失为特征的神经系统退行性疾病。近年研究发现,调节性T细胞(regulatory T cells,Tregs)可能在ALS的发病与进展中发挥重要作用,本文就Tregs的基本功能、在ALS发病中的作用机制及相关临床试验进行综述。
1Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
2Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immuno12010; 11: 7-13.
3Littman DR, Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Ce112010; 140: 845-858.
4Campbell D J, Koch MA. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immuno12011; 11:119-130.
5Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009; 10: 689-695.
6Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the develop- ment and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003: 4: 330-336.
7Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the develop- ment and function of CD4CD25+ regulato T cells. Nat Immunol 2003;4:330-336.
8Khattri R, CoxT, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immuno12003; 4: 337-342.
9Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27: 68-73.
10Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson P J, Whitesell Let al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet2001; 27: 20-21.
