沙格列汀联合阿卡波糖治疗老年糖尿病的临床效果研究

Study on clinical effect of saxagliptin combined with acarbose in the treatment of senile diabetes mellitus

目的研究沙格列汀联合阿卡波糖治疗老年糖尿病的临床效果。方法88例老年糖尿病患者为研究对象,根据治疗方式不同分成实验组与对照组,每组44例。对照组应用阿卡波糖治疗,实验组在对照组基础上联合沙格列汀治疗。比较两组临床疗效、血糖水平、胰岛功能及不良反应发生情况。结果实验组总有效率97.73%高于对照组的81.82%,差异具有统计学意义(P<0.05)。治疗后,实验组患者的空腹血糖及餐后2 h血糖分别为(4.12±0.24)、(7.38±2.18)mmol/L,均低于对照组的(6.11±0.16)、(9.22±2.21)mmol/L,差异均具有统计学意义(P<0.05)。治疗后,实验组空腹胰岛素(FINS)、稳态模型胰岛β细胞功能指数(HOMA-β)水平分别为(9.73±0.62)mIU/L、(43.51±9.63)%,均高于对照组的(9.19±0.84)mIU/L、(37.58±9.86)%,差异均具有统计学意义(P<0.05)。实验组不良反应发生率为6.82%,低于对照组的22.73%,差异具有统计学意义(P<0.05)。结论老年糖尿病患者采用阿卡波糖联合沙格列汀治疗效果显著,与单独应用阿卡波糖患者相比控制血糖效果更佳,可明显提高患者的胰岛相关指标,降低不良反应的发生几率,为患者生命健康提供了有利的保障,值得推广应用。

Objective To study the clinical effect of saxagliptin combined with acarbose in the treatment of senile diabetes mellitus.Methods A total of 88 senile patients with diabetes mellitus as study subjects were divided into experimental group and control group according to different treatment methods,with 44 cases in each group.The control group was treated with acarbose,and the experimental group was treated with saxagliptin on the basis of the control group.The clinical efficacy,blood glucose level,islet function,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 97.73%,which was higher than 81.82%of the control group,and the difference was statistically significant(P<0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose of the experimental group were(4.12±0.24)and(7.38±2.18)mmol/L,which were lower than(6.11±0.16)and(9.22±2.21)mmol/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the fasting insulin(FINS),homeostatic model assessment-β(HOMA-β)of the experimental group were(9.73±0.62)mIU/L and(43.51±9.63)%,which were higher than(9.19±0.84)mIU/L and(37.58±9.86)%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 6.82%of the experimental group was lower than 22.73%of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with acarbose only,combination of acarbose and saxagliptin has better glucose control effect on senile patients with diabetes mellitus,and it can obviously improve the islet-related indicators of patients,reduce the incidence of adverse reactions,which guarantees the life and health of patients,and is worthy of promotion and application.