依达拉奉辅助治疗颈内动脉颅外段狭窄所致短暂性脑缺血发作的价值及对血液流变学的影响

The value of edaravone in the adjuvant treatment of transient ischemia attack caused by extracranial internal carotid artery stenosis and its influence on hemorheology

目的评价颈内动脉颅外段狭窄所致短暂性脑缺血发作治疗中依达拉奉辅助治疗的重要价值。方法246例颈内动脉颅外段狭窄所致短暂性脑缺血发作患者,根据药物治疗方式不同分为1组和2组,每组123例。1组患者行常规药物治疗,2组患者在常规药物治疗基础上行依达拉奉辅助治疗。比较两组患者血液流变学指标、疗效、神经功能缺损情况。结果治疗前,两组患者高切粘度、血浆粘度、低切粘度比较差异无统计学意义(P>0.05);治疗后,2组患者高切粘度、血浆粘度、低切粘度均低于1组,差异具有统计学意义(P<0.05)。治疗后,2组患者治疗总有效率91.06%高于1组的79.67%,差异具有统计学意义(P<0.05)。治疗前,两组患者美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义(P>0.05);治疗后,2组患者NIHSS评分降低幅度大于1组,差异具有统计学意义(P<0.05)。结论颈内动脉颅外段狭窄所致短暂性脑缺血发作治疗中,除常规治疗外,依达拉奉辅助治疗有其重要价值,可改善患者血液流变学指标,提高整体疗效,亦可改善神经功能缺损程度,值得推荐。

Objective To evaluate the value of edaravone in the adjuvant treatment of transient ischemia attack caused by extracranial internal carotid artery stenosis.Methods A total of 246 cases of transient ischemia attack caused by extracranial internal carotid artery stenosis were divided into group 1 and group 2 according to different medications,with 123 cases in each group.Group 1 was treated with conventional medicine,and group 2 was treated with edaravone based on conventional medicine.The hemorheology indexes,clinical efficacy,and neurological deficit were compared between the two groups.Results Before treatment,there was no statistically significant difference in high-shear viscosity,plasma viscosity,low-shear viscosity between the two groups(P>0.05).After treatment,the high-shear viscosity,plasma viscosity,low-shear viscosity of group 2 were lower than those of group 1,and the difference was statistically significant(P<0.05).After treatment,the total effective rate 91.06%of group 2 was higher than 79.67%of group 1,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in National Institutes of Health stroke scale(NIHSS)scores between the two groups(P>0.05).After treatment,the reduction in NIHSS scores of the two groups was greater than that of the first group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of transient cerebral ischemia caused by extracranial internal carotid artery stenosis,in addition to conventional therapy,edaravone adjuvant therapy has its important value,which can improve the levels of hemorheology indexes,improve the overall efficacy and neurological deficit.It is worthy of recommendation.