阿司匹林和低分子肝素治疗习惯性流产的临床效果分析

Analysis of the clinical effect of aspirin and low-molecular-weight heparin in the treatment of habitual abortion

目的分析习惯性流产患者应用阿司匹林与低分子肝素治疗的效果。方法64例习惯性流产患者,根据患者治疗方式差异分为观察组和对照组,每组32例。对照组采用阿司匹林肠溶片单药治疗,观察组采用阿司匹林与低分子肝素联合治疗。比较两组患者妊娠率、活产率、绝对活产率、分娩孕周、流产孕周、分娩出血量以及不良妊娠结局、不良反应(血小板减少、胃肠道反应及瘀斑)发生率。结果观察组活产率82.35%、绝对活产率43.75%,均高于对照组的37.50%、18.75%,差异均具有统计学意义(P<0.05)。观察组患者分娩孕周(39.25±1.54)周长于对照组的(37.52±1.49)周,分娩出血量(350.12±17.67)ml少于对照组的(377.23±20.15)ml,差异均有统计学意义(P<0.05),两组流产孕周比较,差异无统计学意义(P>0.05)。两组妊娠患者子痫前期、新生儿畸形及死胎发生率比较、两组患者血小板减少及胃肠道反应发生率比较,差异均无统计学意义(P>0.05)。观察组妊娠患者流产率17.65%低于对照组的56.25%,观察组患者瘀斑发生率0低于对照组的21.88%,差异均具有统计学意义(P<0.05)。结论习惯性流产患者应用阿司匹林与低分子肝素联合治疗有助于降低流产率,提高活产率,还可有效抑制瘀斑发生率。

Objective To analyze the effect of aspirin and low-molecular-weight heparin in the treatment of habitual abortion.Methods A total of patients with habitual abortion were divided into observation group and control group according to different treatment methods,with 32 cases in each group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with aspirin and low-molecular-weight heparin.The pregnancy rate,live birth weight,absolute live birth rate,gestational weeks of delivery,gestational weeks of miscarriage,blood loss during delivery,adverse pregnancy outcome,and occurrence of adverse reactions(thrombocytopenia,gastrointestinal reactions and ecchymosis)were compared between the two groups.Results The live birth rate 82.35%and absolute live birth rate 43.75%of the observation group were higher than 37.50%and 18.75%of the control group,and the difference was statistically significant(P<0.05).The gestational weeks of delivery(39.25±1.54)weeks of the observation group was longer than(37.52±1.49)weeks of the control group,and blood loss of delivery(350.12±17.67)ml was less than(377.23±20.15)ml of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in gestational weeks of abortion between the two groups(P>0.05).There was no statistically significant difference in incidence of preeclampsia,neonatal deformities,stillbirths,thrombocytopenia and gastrointestinal reactions between the two groups(P>0.05).The abortion rate 17.65%of the observation group was lower than 56.25%of the control group,and ecchymosis rate 0 was lower than 21.88%of the control group.All the difference was statistically significant(P<0.05).Conclusion The combined treatment of aspirin and low-molecular-weight heparin in patients with habitual abortion can help reduce miscarriage rate,increase live births rate,and effectively inhibit the incidence of ecchymosis.