持续胰岛素皮下注射治疗糖尿病合并甲亢的价值

The value of continuous subcutaneous insulin injection in the treatment of diabetes mellitus complicated with hyperthyroidism

目的探讨使用持续胰岛素皮下注射治疗糖尿病合并甲状腺功能亢进症(甲亢)患者的临床效果。方法160例糖尿病合并甲亢患者,根据随机数字表法分为实验组和对照组,每组80例。两组患者首先给予甲硫氧嘧啶进行甲亢的控制,在此基础上,对照组采用胰岛素传统皮下注射治疗,实验组采用胰岛素持续皮下注射治疗。对比两组患者治疗效果、胰岛素使用剂量、不良反应发生率、血糖达标时间及治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]水平。结果实验组患者治疗总有效率为97.50%,高于对照组的88.75%,差异具有统计学意义(P<0.05)。治疗前,两组患者FPG、2 h PG、HbA1c水平对比差异无统计学意义(P>0.05);治疗后,两组患者FPG、2 h PG、HbA1c水平均较本组治疗前有所降低,且实验组患者降低程度大于对照组,差异具有统计学意义(P<0.05)。实验组患者胰岛素使用剂量(41.26±6.13)U少于对照组的(70.041±2.46)U,血糖达标时间(10.27±3.51)d短于对照组的(22.07±6.55)d,差异具有统计学意义(P<0.05)。实验组患者治疗过程中不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论在糖尿病合并甲亢患者的治疗中,使用持续胰岛素皮下注射的方式对患者进行治疗能够有效提高治疗效果,降低患者血糖指标水平,减少胰岛素使用剂量及不良反应的发生,临床使用价值较高。

Objective To discuss the clinical effect of continuous subcutaneous insulin injection in the treatment of diabetes mellitus complicated with hyperthyroidism.Methods A total of 160 cases of diabetes mellitus complicated with hyperthyroidism were divided into experimental group and control group according to random numerical table,with 80 cases in each group.Both groups were first given methionine to control hyperthyroidism.On this basis,the control group was treated with traditional subcutaneous injection of insulin,and the experimental group was treated with continuous subcutaneous injection of insulin.The therapeutic effect,insulin dosage,incidence of adverse reactions,blood glucose reaching standard time and blood glucose indexes[fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2 h PG),glycosylated hemoglobin(HbA1c)]levels before and after treatment were compared between the two groups.Results The total effective rate of the experimental group was 97.50%,which was higher than 88.75%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of FPG,2 h PG and HbA1c between the two groups(P>0.05).After treatment,the levels of FPG,2 h PG and HbA1c of the two groups were lower than those before treatment,and the degree of reduction in the experimental group was greater than that in the control.All the difference was statistically significant(P<0.05).The insulin dosage(41.26±6.13)U of the experimental group was less than(70.04±12.46)U of the control group,and blood glucose reaching standard time(10.27±3.51)d was shorter than(22.07±6.55)d of the control group.All the difference was statistically significant(P<0.05).The incidence of adverse reactions during treatment of the experimental group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of patients with diabetes mellitus and hyperthyroidism,continuous subcutaneous insulin injection can effectively improve the therapeutic effect,reduce the patient’s blood glucose level,reduce the dosage of insulin and the occurrence of adverse reactions,and have high clinical value.