微量元素对牙髓干细胞分化的影响

Effect of trace elements on the differentiation of dental pulp stem cells

牙髓干细胞(dental pulp stem cell,DPSC)是牙髓及牙本质再生研究中关键的优选细胞,具有多向分化的能力。微量元素对DPSC分化的影响是近年口腔组织工程的研究热点。微量元素具有广泛的生理生化功能,一方面可直接调控DPSC分化、迁移和增殖能力;另一方面可通过发挥抗菌及免疫调节作用以及改变支架材料的理化特性,间接影响DPSC分化。明确微量元素在DPSC分化中的作用可为实现牙髓及牙本质再生提供更多的参考依据,本文就近年国内外关于微量元素对DPSC成牙向和成血管向分化的作用及机制研究进行综述。

Dental pulp stem cell(DPSC),with a high capacity of multidirectional differentiation,is the key and preferred cell in the study of dental pulp and dentin regeneration.The effect of trace elements on the differentiation of DPSC is one of the research hotspots in the field of oral tissue engineering in recent years.Trace elements have a wide range of physiological and biochemical functions.It can directly regulate the differentiation,migration and proliferation capacity of DPSC,while can indirectly affect the differentiation of DPSC by exerting antibacterial and immune function regulation or changing the physical and chemical properties of the scaffold material.To clarify the role of trace elements in the differentiation of DPSC can provide more reference for the realization of pulp and dentin regeneration.This paper will review the recent research progress on the effects of relevant trace elements on the differentiation of DPSC into odontogenesis and angiogenesis.