抗Jo-1抗体、抗SSA/Ro52抗体阳性的多发性肌炎/皮肌炎临床特征分析

Clinical feature of polymyositis/dermatomyositis with anti-Jo-1,anti-SSA/Ro52antibodies positive

目的研究抗Jo-1抗体、抗SSA/Ro52抗体与多发性肌炎/皮肌炎(PM/DM)临床特征的关系。方法收集该院收治的111例PM/DM患者资料,根据抗Jo-1抗体、抗SSA/Ro52抗体阴阳性将111例PM/DM患者分成3组。比较各组间临床表现及实验室指标的差异,分析抗Jo-1,抗SSA/Ro52抗体与PM/DM临床特征的相关性。结果阳性组合并间质性肺疾病(ILD)情况明显多于其他两组,而阴性组合并ILD的情况明显低于其他两组(P<0.05)。阴性组的CRP和ESR水平明显低于其他两组(P<0.05)。抗Jo-1(-)SSA/Ro52(+)组的ANA滴度≥1∶320的比例明显高于其他两组(P<0.05)。结论抗Jo-1抗体、抗SSA/Ro52抗体与PM/DM一些临床特征具有一定相关性。抗Jo-1抗体阳性患者更易合并ILD,抗SSA/Ro52(+)患者往往出现ANA阳性情况较多,抗Jo-1、SSA/Ro52(-)患者CRP和ESR水平升高不明显,更易出现皮疹或Gotton征,面部躯体红斑,合并ILD的情况也是最低的。

Objective To study the relationship between anti-Jo-1,anti-SSA/Ro52 antibody and clinical characteristics of polymyitis/dermatomyositis(PM/DM).Methods Data of a total of 111 patients with PM/DM admitted to the First Affiliated Hospital of Dalian Medical University were collected.A total of 111 PM/DM patients were divided into three groups according to the status of anti-Jo-1 and anti-SSA/Ro52 antibody.The differences of clinical manifestations and laboratory indexes among the three groups were compared,and the correlation between anti-Jo-1,anti-SSA/Ro52 antibodies and clinical characteristics of PM/DM was analyzed.Results The positive group had more ILD cases than the other two groups did,while the negative group had less ILD cases than the other two groups did(P<0.05).The levels of CRP and ESR in negative group were significantly lower than those in the other two groups(P<0.05).The positive rate of ANA titer≥1∶320 in anti-Jo-1(-)SSA/Ro52(+)group was significantly higher than that in the other two groups(P<0.05).Conclusion Anti-Jo-1 and anti-SSA/Ro52 antibodies related to some clinical features of PM/DM.Anti-Jo-1 antibody positive patients are more likely to be associated with ILD,and patients with anti-SSA/Ro52 antibody positive tend to be ANA positive.The levels of CRP and ESR are not significantly increased in anti-Jo-1,SSA/Ro52 antibody negative patients whose clinical manifestations of skin rash,Gotton signs and erythema are more common,and the consolidation of ILD is also the lowest.