湖北省某地区居民血清中多氯联苯的负荷水平调查

The human body burden of polychlorinated biphenyls in serum of residents in an area from Hubei Province

采用同位素稀释-高分辨气相-高分辨质谱(HRGC-HRMS)法测定湖北省某地区26名居民血清中12种二噁英类PCBs(dl-PCBs)和6种非二噁英类PCBs(ndl-PCBs)的污染水平。总dl-PCBs(Σdl-PCBs)的浓度范围为366.30~4945.77 pg/g脂肪,平均值为2093.76 pg/g脂肪,PCB 118为dl-PCBs的主要异构体。总ndl-PCBs(Σndl-PCBs)的浓度范围为2671.32~20626.26 pg/g脂肪,平均值为12505.45 pg/g脂肪,PCB 153为ndl-PCBs的特征异构体。血清中Σdl-PCBs的平均浓度水平与年龄呈显著正相关(rs=0.574,P=0.002)。按毒性当量(TEQ)计,总TEQ(ΣTEQdl-PCBs)含量范围为0.07~8.69 pg/g脂肪。

Concentrations of dioxin-like polychlorinated biphenyls(dl-PCBs)and non-dioxin-like PCBs(ndl-PCBs)in 26 serum samples of the residents from Hubei Province were analyzed via high-resolution gas chromatograph tandem high-resolution mass spectrometer(HRGC-HRMS)method.Total concentrations of twelve dl-PCBs(Σdl-PCBs)were in range of 366.30-4945.77 pg/g fat,with the mean value(2093.76 pg/g fat),and PCB 118 was the predominant congener.For six ndl-PCBs,total concentrations(Σndl-PCBs)were in range of 2671.32-20626.26 pg/g fat(mean 12505.45 pg/g fat),and PCB 153 was the predominant congener.Mean concentration ofΣdl-PCBs were significantly and positively associated with age(rs=0.574,P=0.002).The mean World Health Organization toxicity equivalent(WHO-TEQ)of dl-PCBs(ΣTEQdl-PCBs)were range from 0.07 to 8.69 pg/g fat.