VEGF与Ki-67在NSCLC中的表达及其临床意义

Expression of VEGF and Ki-67 in lung tissues of NSCLC and its clinical significance

目的:探讨血管内皮生长因子(VEGF)与核增殖抗原(Ki-67)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法:选取150例NSCLC患者为研究对象,分为死亡组(n=38)和存活组(n=112)。分别取每例患者的癌组织及癌旁组织各1份,采用SP法检测VEGF及Ki-67水平。比较死亡组与存活组、癌组织与癌旁组织VEGF及Ki-67阳性表达水平;分析VEGF和Ki-67阳性表达与NSCLC临床病理特征的关系及癌组织VEGF与Ki-67阳性表达的相关性。结果:死亡组患者癌组织VEGF和Ki-67阳性表达率高于存活组(P<0.05);癌组织VEGF和Ki-67阳性表达率高于癌旁组织(P<0.05);相关性分析显示,VEGF阳性表达与肿瘤直径、淋巴结转移、远处转移及临床分期相关(P<0.05),Ki-67阳性表达与淋巴结转移相关(P<0.05);回归分析显示,癌组织VEGF与Ki-67阳性表达呈正相关(P<0.05)。结论:NSCLC患者中,癌组织中VEGF与Ki-67表达水平较高,且与患者临床病理学特征相关,可作为早期诊断及判断预后的重要依据。

Objective:To investigate the expression of Vascular endothelial growth factor(VEGF)and Nuclear proliferative antigen Ki-67 in lung tissue of non-small cell lung cancer(NSCLC)and its clinical significance.Methods:150 patients with NSCLC were divided into death group(n=38)and survival group(n=112).One piece of lung tissue and one piece of paracancerous tissue were taken from each patient,the levels of VEGF and Ki-67 were detected by SP immunohistochemistry.The positive expression levels of VEGF and Ki-67 in death group and survival group,lung tissue and paracancerous tissue were compared.The relationship between the expression of VEGF and Ki-67 and the clinicopathological features of NSCLC and the correlation between the expression of VEGF and Ki-67 were analyzed.Results:The positive expression rates of VEGF and Ki-67 in cancer tissue of death group were significantly higher than those in survival group(P<0.05).The positive expression rates of VEGF and Ki-67 in lung tissue were higher than those in paracancerous tissue(P<0.05).Correlation analysis showed that the positive expression of VEGF was significantly correlated with tumor diameter,lymph node metastasis,distant metastasis and clinical stage in NSCLC patients(P<0.05).The positive expression of Ki-67 was significantly correlated with lymph node metastasis(P<0.05).Regression analysis showed that there was a positive correlation between VEGF and Ki-67(P<0.05).Conclusion:VEGF and Ki-67 are highly expressed in lung tissues of NSCLC,and are related to the clinicopathological characteristics of patients,which can be used as an important basis for early clinical diagnosis and treatment of NSCLC.