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泼尼松联合伐昔洛韦对带状疱疹急性期患者细胞因子水平及疼痛程度的影响 被引量:5

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摘要 目的观察泼尼松联合伐昔洛韦对带状疱疹急性期患者细胞因子水平及疼痛程度的影响。方法选择2018年5月至2019年5月于某医院治疗的98例带状疱疹急性期患者,采用盲抽法分为观察组(n=49)和对照组(n=49)。对照组给予盐酸伐昔洛韦片+甲钴胺片+阿昔洛韦乳膏治疗,观察组在对照组基础上,加用醋酸泼尼松片治疗。于治疗1周结束时比较两组临床疗效,并对比两组治疗前、治疗1周时疼痛程度及细胞因子水平。结果观察组治疗总有效率为95.92%,高于对照组的83.67%,差异有统计学意义(P<0.05);治疗1周后,两组视觉模拟评分法(VAS)评分均降低,且观察组较对照组低,差异有统计学意义(P<0.05);治疗1周后,两组肿瘤坏死因子-α(TNF-α)水平降低,白介素-2(IL-2)水平升高,且观察组优于对照组,差异有统计学意义(P<0.05)。结论泼尼松联合伐昔洛韦治疗带状疱疹急性期的临床疗效确切,可减轻患者疼痛程度,降低机体炎症反应。
出处 《皮肤病与性病》 2021年第3期445-446,共2页 Dermatology and Venereology
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