结直肠癌类器官生物样本库的建立和应用研究进展

Research progress on establishment and application of organoid biobank of colorectal cancer patients

结直肠癌是世界上最常见的恶性肿瘤之一,我国结直肠癌的发病率和死亡率仍处于上升趋势。以往结直肠癌的研究主要依靠细胞系和异种移植模型,但二者都有一定的局限性,且难以建立大规模生物样本库。类器官模型是一种新兴的体外模型,具有构建周期较短、易于保存以及保留供体异质性的特点,在结直肠癌的基础研究、新药开发、个体化治疗等方面都极具应用价值。

Colorectal cancer is one of the most common malignant tumors in the world.The incidence rate and mortality rate of colorectal cancer in China are still on the rise.In the past,research on colorectal cancer mainly relied on cell lines and xenograft models,but both have certain limitations and it is difficult to establish a large-scale bio bank.Organoid model is a new in vitro model,which has the characteristics of short construction period,easy storage and good preservation of donor heterogeneity.It has great application value in the research of colorectal cancer occurrence and development mechanism,new drug development,individual treatment and so on.