来氟米特联合阿仑膦酸钠治疗老年类风湿关节炎继发骨质疏松患者的临床效果

Clinical effect of leflunomide combined with alendronate sodium in the treatment of elderly patients with osteoporosis secondary to rheumatoid arthritis

目的探讨来氟米特联合阿仑膦酸钠治疗老年类风湿关节炎继发骨质疏松患者的临床效果。方法选取2016年12月至2020年1月我院收治的80例老年类风湿关节炎继发骨质疏松患者作为研究对象,采用随机数字表法将其分为单药组(40例,阿仑膦酸钠)和联合组(40例,来氟米特+阿仑膦酸钠)。比较两组的治疗效果。结果治疗后,两组OC、BALP、PⅠNP水平均较治疗前降低,BMD均较治疗前升高,且联合组优于单药组(P<0.05)。治疗后,两组ESR及CRP、TNF-α、RF水平均较治疗前降低,且联合组低于单药组(P<0.05)。联合组的治疗总有效率高于单药组(P<0.05)。治疗后,两组BP、PF、SA、MF评分均较治疗前降低,且联合组低于单药组(P<0.05)。结论来氟米特联合阿仑膦酸钠治疗老年类风湿关节炎继发骨质疏松的效果显著,可有效改善患者的骨代谢状况,减轻炎症反应,提高生活质量。

Objective To investigate the clinical effect of leflunomide combined with alendronate sodium in the treatment of elderly patients with osteoporosis secondary to rheumatoid arthritis.Methods A total of 80 elderly patients with osteoporosis secondary to rheumatoid arthritis admitted in our hospital from December 2016 to January 2020 were selected as the research objects,and the patients were divided into single drug group(40 cases,alendronate sodium)and combined group(40 cases,leflunomide+alendronate sodium)by random number table method.The therapeutic effects of the two groups were compared.Results After treatment,the levels of OC,BALP and PⅠNP in both groups were lower those before treatment,BMD was higher than that before treatment,and those in the combined group were better than the single drug group(P<0.05).After treatment,ESR and CRP,TNF-α,RF levels in both groups were lower than those before treatment,and those in the combined group were lower than the single drug group(P<0.05).The total effective rate of treatment in the combined group was higher than that in the single drug group(P<0.05).After treatment,BP,PF,SA and MF scores in both groups were lower than those before treatment,and those in the combined group were lower than the single drug group(P<0.05).Conclusion Leflunomide combined with alendronate sodium in the treatment of elderly patients with osteoporosis secondary to rheumatoid arthritis has a significant effect,which can effectively ameliorate the bone metabolism,reduce inflammatory reaction and improve the quality of life.