65例复发性尿路感染患者病原菌的分布情况及耐药性分析

Analysis of pathogen distribution and drug resistance in 65 patients with recurrent urinary tract infection

目的:分析65例复发性尿路感染患者病原菌的分布情况及耐药性。方法:从临沂市中医医院2018年1月至2020年1月接诊的复发性尿路感染患者中选取65例患者作为研究对象。取这些患者的中段尿液进行细菌培养检测,然后分析其检测的结果及其病原菌对抗菌药物的耐药性。结果:这65例患者的中段尿标本中共检出70株病原菌,其中革兰氏阴性菌中有45株(包括大肠埃希菌30株,奇异变形杆菌6株,肺炎克雷伯菌9株),革兰氏阳性菌有25株(包括粪肠球菌14株,腐生葡萄球菌4株,屎肠球菌7株)。这些患者中段尿标本中检出的病原菌对抗菌药物的耐药特点如下:大肠埃希菌对头孢唑林和氨苄西林的耐药率较高,肺炎克雷伯菌对头孢唑林和氨苄西林的耐药率较高,奇异变形杆菌对氨苄西林的耐药率较高,粪肠球菌对利福平和四环素的耐药率较高,腐生葡萄球菌对左氧氟沙星的耐药率较高,屎肠球菌对青霉素的耐药率较高。结论:复发性尿路感染患者的病原菌主要为大肠埃希菌、粪肠球菌。这些病原菌对头孢唑林、氨苄西林、利福平、四环素等抗菌药物的耐药率较高。

Objective:To analyze the distribution and drug resistance of pathogenic bacteria in 65 patients with recurrent urinary tract infection.METHODS:A total of 65 patients with recurrent urinary tract infection admitted to Linyi Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were selected as the research subjects.The middle urine of these patients was collected for bacterial culture test,and then the test results and the resistance of pathogens to antibiotics were analyzed.Results:65 patients were in the middle of the urine specimen of the communist party of 70 strains of pathogenic bacteria detection of gram-negative bacteria have 45 strains(including 30 strains of e.coli,singular proteus strains,69 strains of klebsiella pneumoniae),gram positive bacteria have 25 strains(including 14 in enterococcus strains,staphylococcus saprophytic 4 strains,7 excrement enterococcus strains).The characteristics of antimicrobial resistance of pathogenic bacteria detected in the middle urine samples of these patients were as follows:E.coli to ampicillin and cefazolin,higher percentages of klebsiella pneumoniae to ampicillin and cefazolin,higher percentages of singular proteus,higher percentages of ampicillin,dung enterococcus for rifampicin and higher prevalence of tetracycline resistance,staphylococcus saprophytic,higher percentages of levofloxacin,excrement enterococcus irologic resistance to penicillin is higher.Conclusion:The main pathogens of recurrent urinary tract infection are Escherichia coli and Enterococcus faecalis.These pathogens were resistant to cefazolin,ampicillin,rifampicin,tetracycline and other antimicrobial drugs.