用血栓弹力图检查评估舒血宁注射液对2型糖尿病患者凝血功能影响的效果

The effect of Shuxuening injection on blood coagulation function in patie nts with type 2 diabetes mellitus was evaluated by thromboelastography

目的:探讨用血栓弹力图(TEG)检查评估舒血宁注射液对2型糖尿病(T2DM)患者凝血功能影响的效果。方法:选择同济大学附属同济医院收治的48例T2DM患者与在该医院进行体检的30例健康人作为研究对象。将其中48例T2DM患者设为T2DM组,将其中30例健康人设为对照组。对T2DM组患者在进行常规治疗的基础上,采用舒血宁注射液进行治疗。对两组研究对象均进行TEG检查(在对照组健康人体检时进行TEG检查,在T2DM组患者治疗前及治疗后分别进行TEG检查),比较其各项TEG指标。结果:治疗前T2DM组患者TEG的R值、K值均小于对照组健康人,TEG的α角、MA值、CI值均大于对照组健康人,P<0.05。治疗后,T2DM组患者TEG的R值、K值均大于治疗前,TEG的α角、MA值、CI值均小于治疗前,P<0.05。治疗后T2DM组患者TEG的R值、K值均小于对照组健康人,TEG的α角、MA值、CI值均大于对照组健康人,P<0.05。结论:T2DM患者的血液呈高凝状态,用舒血宁注射液对其进行治疗可改善其血液高凝的状态,但难以彻底纠正。用TEG检查评估舒血宁注射液对T2DM患者凝血功能影响的效果显著,能有效地反映治疗前后患者凝血功能的变化,评估舒血宁注射液的疗效,且能为患者抗凝方案的制定提供参考依据。

Objective:To evaluate the effect of Shuxuening injection on blood coagulation function in type 2 diabetes mellitus(T2DM)patients by using thromboelastography(TEG).Methods:48 T2DM patients admitted to Tongji Hospital of Tongji University and 30 healthy subjects underwent physical examination in the hospital were selected as the research subjects.Among them,48 patients with T2DM were assigned to the T2DM group,and 30 healthy people were assigned to the control group.On the basis of conventional treatment,patients in T2DM group were treated with Shuxuening injection.The subjects in both groups were tested for TEG(during the physical examination of healthy subjects in the control group,before and after treatment in the T2DM group),and their various TEG indicators were compared.Results:Before treatment,the R and K values of TEG in T2DM group were lower than those in control group,and theαAngle,MA and CI values of TEG were higher than those in control group(P<0.05).After treatment,the R value and K value of TEG in T2DM group were higher than before treatment,and theαAngle,MA value and CI value of TEG were lower than before treatment,P<0.05.After treatment,the R value and K value of TEG in T2DM group were lower than those in control group,and theαAngle,MA value and CI value of TEG were higher than those in control group(P<0.05).Conclusion:Blood hypercoagulability is present in T2DM patients.The treatment with Shuxuening injection can improve the hypercoagulability,but it is difficult to correct it completely.TEG examination and evaluation of the effect of Shuxuening injection on the coagulation function of T2DM patients is significant,which can effectively reflect the changes of the coagulation function of patients before and after treatment,evaluate the efficacy of Shuxuening injection,and provide a reference for the formulation of anticoagula tion programs for patients.