67例甲磺酸加贝酯不良反应报告分析

Analysis of adverse reactions of gabexate mesylate in 67 cases

目的探讨甲磺酸加贝酯导致不良反应(ADR)的一般规律和特点,为临床合理用药提供参考。方法从两家医院药品不良反应监测管理系统中调取2014年1月~2019年3月填报的甲磺酸加贝酯相关ADR报告共67例,通过回顾性统计法对ADR报告进行综合分析。结果67例ADR患者中,男女发生率差异无统计学意义,年龄>60岁的ADR发生率累计超过50%,多在用药30 min内发生,主要累及器官/系统:皮肤黏膜(78.38%)、循环系统(13.52%)、消化系统(4.05%)、中枢神经系统(4.05%),主要临床表现为皮疹、瘙痒、输注部位红肿疼痛、心慌、胸闷、潮红、血压下降、口干、恶心、呕吐等。结论需重视甲磺酸加贝酯引起的不良反应,加强临床用药指导,确保用药安全。

Objective To explore the general rules and characteristics of adverse reactions(ADR)caused by gabeste mesylate,and to provide a reference for clinical rational drug use.Methods A total of 67 ADR reports related to gabecyl mesylate reported from January 2014 to March 2019 were collected from the ADR monitoring and management system of two hospitals.A retrospective statistical method was used to comprehensively analyze the ADR report.Results Among the 67 patients with ADR,there was no significant difference between women and men.The incidence of ADR over 60 years of age was accumulated more than 50%,and most of them occurred within 30 minutes of medication.The main organs/systems were involved:skin and mucosa(78.38%),circulatory system(13.52%),digestive system(4.05%),central nervous system(4.05%).The main clinical manifestations are rash,itching,redness,swelling and pain at the infusion site,palpitation,chest tightness,flushing,decreased blood pressure,dry mouth,nausea,avomiting and so on.Conclusion It is important to pay attention to the adverse reactions caused by gabexate mesylate,strengthen clinical rational use of drugs,in order to ensure the safe drug use in clinic.