可见光催化的烯烃胺化反应的研究进展

Progress in Amination of Alkenes via Visible Light⁃Photoredox Catalysis

C-N键的构建反应是现代有机合成中重要的研究领域。在C-N键的构建方法中,烯烃的胺化反应是一类通过一步反应就可以高效合成出多位点产物的反应。近年来,随着光催化氧化还原反应的不断发展,烯烃的胺化反应取得了一些重要的突破。通过光催化氧化还原反应,利用可见光为绿色能源,加入一定量的催化剂,可以将廉价易得的烯烃类化合物转化为含有生物活性的胺类化合物中间体。该类反应可以在合成化学、材料化学、医药等领域得到广泛的应用。因此,发展光催化的烯烃胺化反应是非常有必要的。从烯烃的酰胺化氢化反应、胺化氢化反应、卤代胺化反应、胺化烷氧基化反应以及胺化烷基化反应等方面入手,对近5年以上5个方面的研究进展进行简单的归纳和总结。

The construction of C-N bond is an important research field in modern organic synthesis.For C-N bond construction methods,the amination of olefins is the most efficient way which can synthesize multi⁃site products in one⁃step.With the development of photocatalytic redox reactions,some important breakthroughs have been made in the field of amination of alkenes.Using the photocatalytic redox reaction with visible light as a green energy source,the cheap olefin compounds can be catalyzed into biologically active amine compound intermediates.This type of reaction can be widely used in synthetic chemistry,material chemistry,medicine and other fields.Therefore,it is necessary to develop photocatalytic amination of olefins.The research progress over 5 years in five areas,including olefin amidation hydrogenation reaction,olefin amination hydrogenation reaction,olefin halogenation amination reaction,olefin amination alkoxylation reaction,and olefin amination alkylation reaction,is briefly summarized.