肾移植术后JC病毒感染的最新进展

The latest progress on JC virus infection after renal transplantation

JC病毒(JCV)是多瘤病毒家族的成员之一,在人群中的感染率约为70%,初次感染后常潜伏存在。在免疫抑制的个体中,特别是细胞免疫功能低下的情况下,JCV可以重新激活并导致严重的临床表现。近年来,JCV与肾移植术后并发症的相关性逐渐被重视,已有JCV相关性肾病(JCVAN)的报道。现就JCV的流行病学、分子生物学、体内感染过程,JCV与肾移植术后并发症以及JCV与BKV的相互关系进行综述,以期为肾移植术后免疫抑制方案的调整提供参考。

JC virus(JCV)is a member of polyomaviridae family that infects approximately 70%of the population worldwide.JCV constantly stays in a latent state after the primary infection.In immunosuppressed individuals,especially under the circumstances of low cellular immune function,JCV may be reactivated and lead to severe clinical manifestations.In recent years,the correlation between JCV and complications after renal transplantation has captivated widespread attention.JCV-associated nephropathy(JCVAN)has been reported.Here,latest research progresses on the epidemiology,molecular biology,in vivo infection process,JCV and complications after renal transplantation,and the relationship between JCV and BKV were reviewed,aiming to provide reference for the adjustment of immunosuppressive regimen following renal transplantation.