陕西省鄠邑区60-70岁人群接种肾综合征出血热疫苗后保护效果和免疫原性

Vaccine effectiveness and immunogenicity of hemorrhagic fever with renal syndrome vaccine among 60-70-year-olds in Huyi district of Shaanxi province

目的评价60-70岁人群接种肾综合征出血热(Hemorrhagic fever with renal syndrome,HFRS)疫苗的保护效果(Vaccine effectiveness,VE)和免疫原性。方法采取回顾性配对设计,在陕西省鄠邑区筛选60-70岁HFRS疫苗接种者(A组)和未接种者(B组),收集HFRS发病信息,计算疫苗VE;检测A组、B组和50-60岁适龄HFRS疫苗接种者(C组)血清HFRS-IgG抗体和/或汉坦病毒中和抗体,比较抗体阳性率。结果A、B组HFRS发病率分别为0.52%(1/193)、2.07%(4/193),接种HFRS疫苗后平均6.10年的VE为74.88%(95%CI:20.44%-129.56%)。A、B、C组各106人进行了抗体检测,三组HFRS-IgG阳性率分别为33.96%、18.87%、32.08%(A组vs B组:χ^(2)=6.10,P=0.021;A组vs C组:χ^(2)=0.08,P=0.890);A、C组汉坦病毒Ⅰ型中和抗体阳性率分别为22.64%、15.09%(χ^(2)=1.88,P=0.230),Ⅱ型阳性率均为12.26%。结论60-70岁人群接种HFRS疫苗具有良好的保护效果和免疫原性。

Objective To evaluate vaccine effectiveness(VE)and immunogenicity of hemorrhagic fever with renal syndrome(HFRS)vaccine among 60-70-year-olds.Methods We used a retrospective matching design to match 60-70-year-old individuals who received HFRS vaccine(group A)with people who did not receive the vaccine(group B)in Huyi district of Shaanxi province;we obtained HFRS incidence rates to determine VE.We tested serum samples for HFRS-IgG and/or neutralizing antibodies among group A,group B,and 50-60-year-olds who were age-eligible for HFRS vaccination(group C)to compare sero-positivity.Results Incidence rates of HFRS in groups A and B were 0.52%(1/193)and 2.07%(4/193),respectively;VE at an average of 6.10 years after vaccination was 74.88%(95%CI:20.44%-129.56%).Groups A,B,and C each included 106 subjects for antibody detection;positivity rates of HFRS-IgG antibody for the 3 groups were 33.96%,18.87%,and 32.08%,respectively(group A vs group B:χ^(2)=6.10,P=0.021;group A vs group C:χ^(2)=0.08,P=0.890).Positivity rates of neutralizing antibody against hantavirus type I were 22.64%and 15.09%in groups A and C(χ^(2)=1.88,P=0.230),and against hantavirus type II were 12.26%in the two groups.Conclusions HFRS vaccination showed good vaccine effectiveness and immunogenicity among 60-70-year-old people.