肺部超声联合氨基末端脑钠肽前体在急性呼吸困难患者鉴别诊断中的应用研究

Application of combination of lung ultrasound and N-terminal pro-brain natriuretic peptide for differentiating on patients with acute dyspnea

目的探讨肺部超声联合氨基末端脑钠肽前体(NT-proBNP)对心源性和肺源性急性呼吸困难患者的鉴别诊断价值。方法回顾性分析2018年1月至2019年12月因急性呼吸困难急诊入住该院的156例患者的临床资料,将其分为心源性组(93例)和肺源性组(63例)。记录两组患者的肺部超声检查结果、NT-proBNP水平、改良波士顿评分和其他实验室指标,采用受试者工作特征(ROC)曲线分析肺部超声联合NT-proBNP对呼吸困难鉴别诊断的效能。结果肺部超声联合NT-proBNP鉴别诊断急诊呼吸困难的敏感度和特异度均为100%,曲线下面积为0.99。结论肺部超声联合床旁快速NT-proBNP检测是鉴别心源性和肺源性急性呼吸困难的可靠方法。

Objective To evaluate the combination of lung ultrasound and N-terminal pro-brain natriuretic peptide(NT-proBNP)for differentiating of patients with cardiogenic and pulmonary dyspnea.Methods Clinical data of 156 patients admitted to this hospital for acute dyspnea from January 2018 to December 2019 were retrospectively analyzed,and they were divided into cardiogenic group(93 cases)and pulmonary group(63 cases).Lung ultrasound examination results,NT-proBNP level,modified Boston score and other laboratory indicators of the two groups of patients were recorded.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of lung ultrasound combined with NT-proBNP for the differential diagnosis of dyspnea.Results The sensitivity and specificity of lung ultrasound combined with NT-proBNP in differential diagnosis of emergency dyspnea were 100%,and the area under the curve was 0.99.Conclusion Pulmonary ultrasound combined with bedside rapid NT-proBNP detection is a reliable method for the identification of cardiogenic and pulmonary acute dyspnea.