SIRT1在慢性肾脏病中的研究进展

Research progress of SIRT1 in chronic kidney disease

沉默信息调节因子1(SIRT1)是一种去乙酰化酶,当肾脏疾病发生时,可通过调节水钠平衡、调控自噬及抗氧化应激、抗纤维化等生物学效应保护肾脏。慢性肾脏病病程长且缺乏有效治疗手段,威胁着患者的生命健康。寻找有效的药物作用靶点对于改善患者预后具有重要意义。近年来,SIRT1与慢性肾脏病关系及其激动剂药用价值的深入研究,为慢性肾脏病的治疗带来新思路。该文就SIRT1及其在慢性肾脏病中作用的研究进展进行综述。

Silence information regulator 1(SIRT1)is a kind of deacetylase,which can protect the kidney by regulating water-sodium balance,regulating autophagy,anti-oxidative stress,anti-fibrosis and other biological effects when kidney diseases occur.Chronic kidney disease has a long course and lack of effective treatment,threatening the life and health of patients.Finding effective drug targets is of great significance to improve the prognosis of patients.In recent years,in-depth studies on the relationship between SIRT1 and chronic kidney disease and the medicinal value of SIRT1 agonists have brought new ideas for the treatment of chronic kidney disease.This article reviews the research progress of SIRT1 and its role in chronic renal disease.