卡培他滨不同给药方案用于晚期消化道肿瘤中的治疗效果及不良反应观察

Effect and Adverse Effect of Different Administration Schemes of Capecitabine in the Treatment of Advanced Gastrointestinal Tumors

目的研究卡培他滨不同给药方案用于晚期消化道肿瘤中的治疗效果及不良反应发生率。方法在我院2017年4月至2019年4月收治的晚期消化道肿瘤患者中选取97例为研究对象,按照随机数表法分两组观察组和对照组,观察组49例,对照组48例,对照组2周为1个疗程,连续治疗3个疗程,观察组3周为1个疗程,连续治疗3个疗程,对比两组治疗效果。结果与对照组比较,观察组的各个不良反应发生率均较低,临床治疗效果较好,各项生活质量评分均较高,临床获益率较高,两组各项对比差异均比较显著,P<0.05。结论在晚期消化道肿瘤患者中选择适当的卡培他滨药物治疗方式,可以有效的降低不良反应的发生,提升临床治疗效果。

Objective To study the therapeutic effects and adverse reaction rates of different dosage regimens of capecitabine for advanced gastrointestinal tumors.Methods A total of 97 patients with advanced gastrointestinal tumors admitted in our hospital from April 2017 to April 2019 were selected as the research objects.According to the random number table method,they were divided into two observation groups and control groups.The observation group was 49 cases and the control group was 48 cases,the control group was treated for 2 weeks as a course of treatment and 3 consecutive courses of treatment,and the observation group was treated for 3 weeks as a course of treatment and 3 consecutive courses of treatment.The treatment effects of the two groups were compared.Result Compared with the control group,the observation group has a lower incidence of adverse reactions,a better clinical treatment effect,a higher quality of life scores,a higher clinical benefit rate,and significant differences in each comparison of both group,P<0.05.Conclusion Choosing appropriate capecitabine drug treatment in patients with advanced gastrointestinal tumors can effectively reduce the occurrence of adverse reactions and improve clinical treatment effects.