摘要
椎间盘退变(intervertebral disc degeneration,IDD)近年来因其发病率的不断升高以及发病年龄提前得到广泛关注,其引起的脊柱疾病,不同程度上的降低了人类生活质量。其退变机制的不确定性使得其治疗方式较为复杂,为进一步探究椎间盘退变的病因病理,本文将借助国内外关于椎间盘退变性疾病的相关文献,对目前主要的造模方法做一综述,希望通过比较不同椎间盘退变动物模型之间的差异,选择出能够全面模拟人类椎间盘退变的造模方法。
In recent years,owing to the increasing incidence of intervertebral disc degeneration and age-related early onset,spinal diseases caused by intervertebral disc degeneration have reduced quality of life.The uncertainty of the mechanism of degeneration increases the complexity of the treatment method.To further explore the causes of intervertebral disc degeneration and its pathology,we conducted a literature review to explore the differences between animal models of intervertebral disc degeneration to enable the optimal simulation of human intervertebral disc degeneration to be identified.
作者
颜昊
贾永伟
翟伟峰
YAN Hao;JIA Yongwei;ZHAI Weifeng(Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China;Department of Spine Surgery,Guanghua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200052)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2021年第3期387-392,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金面上项目(81972118)
上海市卫生和计划生育委员会面上项目(201840361)
上海市长宁区科学技术委员会重点项目(CNKW2017Z05)。
关键词
椎间盘退变
动物模型
造模方法
intervertebral disc degeneration
animal models
building methods
