摘要
Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information related to understand the glymphatic system dynamics, pathways, and provide quantitative maps for diagnosis, monitoring and prognosis of the disease. The non-invasive nature of MRI might more readily help with translation of glymphatic measurements from the laboratory to the clinic.
基金
This work was supported by NIH grants RF1 AG057494,RO1 NS108463,RO1 NS097747 and R21 AG052735.I thank Li Zhang,Esmaeil Davoodi-Bojd,Guangliang Ding,Zhenggang Zhang and Michael Chopp for their contribution of the glymphatic studies in the Department of Neurology,Henry Ford Hospital.
