Mechanisms of hydrocephalus after intraventricular haemorrhage in adults

Intraventricular haemorrhage(IVH)is defined as the eruption of blood in the cerebroventricular system and occurs mostly secondary to intracerebral haemorrhage(ICH)in adults.Hydrocephalus is a severe complication of IVH that can serve as an independent predictor of increased mortality.In this mini-review,we focus on the mechanisms of hydrocephalus after adult IVH,including blood-clot blockage,barrier impairment,inflammation and blood components,and attempt to reconcile the current research findings into a unified framework.We expect our theoretical framework to help guide future clinical and basic research leading to improved monitoring and intervention for IVH and subsequent hydrocephalus.