四联疗法治疗幽门螺杆菌阳性的慢性荨麻疹临床观察

Clinical observation of quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori positive

目的:观察四联疗法治疗幽门螺杆菌阳性的慢性荨麻疹临床效果。方法:在我院2018年9月至2019年9月期间收治的所有慢性荨麻疹合并幽门螺杆菌感染患者中随机抽取126例,采用不同的治疗方式进行治疗,并将此作为依据平均分成两组,保证每组各有患者63例。对照组患者采用常规抗组胺疗法进行治疗,而实验组则在此基础上加用四联疗法进行治疗,比较两组患者经过治疗之后所产生的临床效果以及不良反应发生率。结果:实验组患者的不良反应发生率显著低于对照组,而治疗有效率相反高于对照组,差异表示统计学意义显著(P<0.05)。结论:采用四联疗法治疗慢性荨麻疹合并幽门螺杆菌感染者可取得显著的临床治疗效果,不仅如此还能够有效降低患者的不良反应发生率,具有极高的临床应用价值。

Objective:To observe the clinical effect of quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori positive.Methods:126 patients with chronic urticaria complicated with Helicobacter pylori infection in our hospital from September 2018 to September 2019 were randomly selected and treated with different treatment methods.They were equally divided into two groups according to this,with 63 patients in each group.The control group was treated with conventional antihistamine therapy,while the experimental group was treated with quadruple therapy on the basis of conventional antihistamine therapy.Results:the incidence of adverse reactions in the experimental group was significantly lower than that in the control group,while the effective rate was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori infection can achieve significant clinical effect,not only that,but also can effectively reduce the incidence of adverse reactions in patients with high clinical application value.