摘要
1型糖尿病(type 1 diabetes mellitus,T1DM)是一种器官特异性的胰岛β细胞不可逆损伤而导致的自身免疫疾病,目前尚无有效的根治方法。每日注射外源胰岛素是1型糖尿病患者维持生命的主要方法。胰岛移植是目前治疗1型糖尿病的有效方法,但受到供体严重缺乏以及需要终身免疫抑制等的限制。利用干细胞诱导生成胰岛β细胞移植治疗1型糖尿病是一种旨在恢复胰岛功能,取代外源胰岛素的新型生物疗法。对近年来诱导干细胞分化为胰岛β细胞开展治疗的研究进展进行综述,为干细胞移植治疗糖尿病的临床应用研究提供参考。
Type 1 diabetes mellitus(T1DM)is an organ-specific autoimmune disease caused by irreversible damage to pancreaticβcells.No effective cure for T1DM has been established.Daily injection of exogenous insulin is the primary way to maintain quality of life in patients with T1DM.Although islet transplantation is an effective therapy for T1DM,it is limited by the severe shortage of donors and permanent immunosuppression.The replacement of pancreaticβcells by stem cells is an innovative biomedical therapy that aims to restore the function of the islets and replace exogenous insulin in patients with T1DM.This review summarizes the progress in the research of stem cell-differentiated pancreaticβcell treatment in recent years and provides references for the clinical application of stem cell therapy in the treatment of T1DM.
作者
张芮
司维
ZHANG Rui;SI Wei(Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China;State Key Laboratory of Primate Biomedical Research,Kunming 650500)
出处
《中国比较医学杂志》
CAS
北大核心
2021年第6期128-132,共5页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(31872973)。
关键词
干细胞
诱导分化
胰岛Β细胞
1型糖尿病
stem cells
induced differentiation
pancreaticβcells
type 1 diabetes mellitus
