维生素D治疗多囊卵巢综合征维生素D缺乏患者的效果

Effects of vitamin D in treatment of patients with polycystic ovary syndrome and vitamin D deficiency

目的:观察维生素D治疗多囊卵巢综合征(PCOS)维生素D缺乏患者的效果。方法:选取68例PCOS维生素D缺乏患者为研究对象,采用随机数字表法分为研究组和对照组各34例。对照组采用常规治疗,研究组在对照组基础上服用维生素D治疗,比较两组治疗前后糖代谢指标水平、胰岛素抵抗指数(HOMA-IR)、维生素D水平、内脏脂肪指数(VAI)、脂联素(APN)水平、激素水平和不良反应发生率。结果:治疗后,研究组空腹血糖水平、空腹胰岛素水平、HOMA-IR和VAI均低于对照组,25-羟基维生素D和APN水平均高于对照组,差异有统计学意义(P<0.05);两组促黄体生成素(LH)水平、卵泡刺激素(FSH)水平、睾酮水平、LH/FSH和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:在常规治疗基础上采用维生素D治疗PCOS维生素D缺乏患者可降低糖代谢指标水平、HOMA-IR和VAI,提高25-羟基维生素D和脂联素水平,效果优于单纯常规治疗。

Objective:To study effects of vitamin D in treatment of patients with polycystic ovary syndrome(PCOS)and vitamin D deficiency.Methods:68 PCOS and vitamin D deficiency patients were selected as the research objects,and were divided into study group and control group by using the random number table method,34 cases in each group.The control group was given conventional treatment,while the study group was treated with vitamin D on the basis of that of the control group.The glucose metabolism index levels,insulin resistance index(HOMAIR),vitamin D level,visceral adiposity index(VAI),and adiponectin(APN)and hormone levels as well as the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the fasting blood glucose levels,the fasting insulin levels,the HOMA-IR and the VAI of the study group were lower than those of the control group;the levels of 25-hydroxyvitamin D and APN were higher than those of the control group;and the differences were statistically significant(P<0.05).However,there were no significant differences in the levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),testosterone,LH/FSH and the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of the conventional treatment,the use of vitamin D in the treatment of the patients with PCOS and vitamin D deficiency can reduce the levels of glucose metabolism index,HOMA-IR and VAI,and increase the levels of 25-hydroxyvitamin D and adiponectin.Moreover,it is superior to single conventional treatment.